肠抑胃肽与2型糖尿病
摘要
肠抑胃肽(GIP)促进胰岛B细胞分泌胰岛素的作用减低或缺失是2型糖尿病发病机制的重要环节,具体可能与GIP受体的异常有关。应用GIP降解酶抑制剂、化学修饰的GIP可改善血糖水平,转染了GIP/胰岛素基因序列的K细胞能以血糖依赖方式分泌人胰岛素,并能在B细胞功能缺失下维持血糖。
出处
《国外医学（内分泌学分册）》
2003年第4期245-247,共3页
Foreign Medical Sciences(Section of Endocrinology)
参考文献19
-
1Damholt A B, Kofod H, Buchan A M. Immunocytochemical evidence for a paracrine interaction between GIP and GLP-1-producing cells in canine small intestine [J]. Cell Tissue Res, 1999,98:287-293. 被引量：1
-
2Kindmark H, Pigon J, Efendic S, et al. Glucose-dependent insulinotropic hormone potentiates the hypoglycemic effect of glibenclamide in healthy volunteers: evidence for an effect on insulin extraction[J]. J Clin Endocrinol Metab,2001,86:2015-2019. 被引量：1
-
3Vilsbφll T, Krarup T, Deacon C F, et al. Reduced postprandial concentrations of intact biologically active glueagonlike peptide 1 in type 2 diabetic patients [ J ]. Diabetes,2001,50:609-613. 被引量：1
-
4Tseng C C, Zhang X Y. Role of regulator of G protein signalling in desensitization of the glucose-dependent insulinotropic peptide receptor [J] . Endocrinology, 1998,139:4470-4475. 被引量：1
-
5Hinke S A, Panly R P, Ehses J, et al. Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (βTC-3) cells to glucose-dependent insulinotropic polypeptide [ J]. J Endocrinol, 2000,165 : 281-291. 被引量：1
-
6Lynn P C, Pamir N, Ng E H, et aJ. Defective glucose-de-pendent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats [J]. Diabetes,2001,50:1004-1011. 被引量：1
-
7Meier J J, Hucking K, Hoist J J, et al. Reduced insulinotropic effect of Gastric Inhibitory Polypeptide in first-degree relatives of patients with type 2 diabetes [ J ]. Diabetes,2001,50: 2497-2504. 被引量：1
-
8Deacon C, Danielsen P, Klarskov L, et al. Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic effects in anesthetized pigs [ J ]. Diabetes,2001,50:1588-1597. 被引量：1
-
9Marguet D, Baggio L, Kobayashi T, et al. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 [J]. Proc Nail Acad Sci USA,2000,97:6874-6879. 被引量：1
-
10O'Harte F P M, Mooney M H, Flair P R. NH2-terminally modified Gastric Inhibitory Polypeptide exhibits amino-pepti-dase resistance and enhanced antibyperglycemic activity[J] .Diabetes, 1999,48 : 758-765. 被引量：1
-
1孙玲君,邵加庆,王坚.肠抑胃肽与2型糖尿病[J].中国全科医学,2008,11(8):718-721. 被引量：4
-
2沈晓霞,李光伟.DPP-4抑制剂的多中心临床试验研究进展[J].药品评价,2009,6(1):24-25. 被引量：2
-
3朱蕾,吴龙奇,张莉,付鹏,张丽,王海娇.幽门螺杆菌感染对非糖尿病人群糖代谢的影响[J].山东医药,2017,57(4):54-56. 被引量：3
-
4宝凤芹.糖尿病患者血液流变学结果的分析[J].实用糖尿病杂志,2006,2(2):40-40.
-
5张政军,毛积芳,张志珍.糖依赖性胰岛素释放肽促胰岛素分泌及脂肪分解效应[J].世界华人消化杂志,2001,9(4):435-436.
-
6彭隽,贾汝汉.CD36在慢性肾脏病中的作用[J].中国医师进修杂志,2012,35(31):70-72. 被引量：1
-
7富晶,马荣,石宏晏,王敏杰.单纯性脂肪肝患者运动前后血脂水平变化的探讨[J].中国医疗前沿,2008,3(17). 被引量：1
-
8潘立镇,白日星,宋茂民,李有国,Lisa Zhou,钟志强,许俊,袁辉生,崔真.胃旁路手术对糖耐量正常犬血糖、糖依赖性胰岛素释放肽和胰高血糖素样肽-1的影响[J].中华外科杂志,2013,51(9):831-833.
-
9周雪,谢云.肠抑胃肽胰腺外作用的研究进展[J].国际内分泌代谢杂志,2007,27(2):92-94. 被引量：1
-
10杨红旺,刘洋,袁勃,孟雁.GLP-1的生理作用与临床[J].中国糖尿病杂志,2009,17(1):78-80. 被引量：26
