摘要
目的 :观察奥沙利铂联合 5 -氟脲嘧啶、甲酰四氢叶酸钙对晚期大肠癌治疗近期疗效及延长生存期的应用价值。方法 :将 6 3例晚期大肠癌随机分为实验组和对照组 ,实验组采用奥沙利铂 130mg/m2 静滴 2h ,第 1天 ;加甲酰四氢叶酸钙 2 0 0mg/m2 +5 -氟脲嘧啶 4 0 0mg/m2 静滴 8h以上 ,第 1～ 5d ;对照组甲酰四氢叶酸钙2 0 0mg/m2 +5 -氟脲嘧啶 4 0 0mg/m2 静滴 8h以上 ,第 1～ 5d。结果 :实验组总有效率为 5 6 .3% ,中位无进展生存期为 10 .5月 ,中位生存期为 2 1.6月 ;对照组分别为 2 2 .6 % ,5 .8月及 13.7月 ,两组相比 ,差异有显著性 (P<0 .0 5 ) ,毒副反应两组相比 ,实验组的神经毒性反应高于对照组 (Q <0 .0 5 ) ,但在其他毒副反应方面 ,两组相比 ,差异无显著性 (P >0 .0 5 )。结论 :奥沙利铂联合 5 -氟脲嘧啶、甲酰四氢叶酸钙对晚期大肠癌治疗有明显疗效 ,能延长生存期 ,毒副反应多数病人能耐受。
Objective:To observe the clinical near curative effect and extending survival period of oxaliptatin with 5-FU/ CF in the treatment of advanced colorectal cancer.Methods:Sixty-three patients of advanced colorectal cancer were selected and randomly divided into two groups: the experimental group and the control group, the experimental group was adopt oxaliplation 130mg/m 2 intravenous infusion 2h (first day ), CF200mg/m 2+5-Fu400mg/m 2 intravenous infusion above 8h (from first day to fifth day); The control group was only adopt CF200mg/m 2+5-Fu400mg/m 2 intravenous infusion above 8h (from first day to fifth day).Results:The total response rate of the experimental group was56.3%.The median PFS was 10.5 months and the median survival was 21.6 months. The total response rate of the control group was only 22.6%.The median PFS was 5.8 months and the median survival was 13.7 months. There was significant difference in the total response rate, the median PFS and the median survival between the two group ( P <0.05).The neural toxic reaction the experimental group exceeded that of the control group ( P <0.05).There was no significant difference in othertoxic reactions ( P >0.05) .Conclusions:Oxaliplatin with 5-FU/ CF was obviously curative effect in the treatment of advanced colorectal cancer. It could effectively extend the survival period. Most of patients could be tolerant in in the toxic reaction.
出处
《中国现代医学杂志》
CAS
CSCD
2003年第14期81-83,共3页
China Journal of Modern Medicine
