摘要
在水/乙酸乙酯体系中,利用水溶性甲壳素分子上的自由氨基引发N-羧基-l-亮氨故-环内酸酐(NCA)的开环聚合,将聚l-亮氨酸引入到甲壳素的侧链,制备了多糖/多肽杂化材料。由于反应中使用了水溶性甲壳素,反应可以在温和的条件下进行,且反应的转化率和接枝效率均较高。接枝共聚物的多肽链段长度可以通过NCA的投料量进行控制,得到各种肽链长度的接枝共聚物。通过元素分析、红外光谱、X射线衍射、差热分析和溶解实验等表征了接枝共聚物,结果表明:接枝共聚物的性能受多肽链段的长度影响较大,随着肽段长度的增加出现了a-螺旋结构。
A type of polysaccharide/polypeptide hydride material, chitin derivatives having polypeptide side chains, was prepared by the graft copolymerization of l -leucine N-carboxy anhydride (NCA) onto water-soluble chitin in water/ethyl acetate. The polymerization proceeded quite smoothly, and both the conversation and grafting efficiency were very high owing to the mild polymerization conditions which became feasible by using the water-soluble chitin. The length of the polypeptide chains was easily regulated by the mount of NCA, and the graft copolymers with side chains of various lengths were obtained reproducibly. The results of elementary analysis, infrared spectroscopy, X-ray analysis,differential scanning calorimetry and solubility tests of the copolymers are largely dependent on the side-chain length, and influence of α -helix formation by the side chains is evident.
出处
《功能高分子学报》
CAS
CSCD
2003年第2期137-141,共5页
Journal of Functional Polymers
基金
国家自然科学基金(20174018)
