摘要
目的探讨雷贝拉唑治疗幽门螺杆菌相关性胃溃疡的临床疗效。方法选取郑州大学附属洛阳中心医院2014年2月—2015年2月收治的78例幽门螺杆菌相关性胃溃疡患者,随机分为研究组和对照组,各39例。对照组采用奥美拉唑肠溶胶囊治疗,研究组采用雷贝拉唑钠肠溶片治疗,观察两组患者的临床疗效、幽门螺杆菌清除率、不良反应和复发情况。结果两组患者总有效率、不良反应发生率比较,差异无统计学意义(P>0.05)。研究组幽门螺杆菌清除率高于对照组,远期复发率低于对照组,差异有统计学意义(P<0.05)。结论雷贝拉唑治疗幽门螺杆菌相关性胃溃疡的临床疗效与奥美拉唑相当,不良反应少,且远期复发率较低。
Objective To investigate the clinical efficacy of rabeprazole in the treatment of helicobacter pylori correlation gastric ulcer. Methods A total of 78 case of patients with helicobacter pylori correlation gastric ulcer were selected from February 2014 to February 2015 in Luoyang Center Hospital Affiliated to Zhengzhou University,which were randomly divided into the study group and the control group,39 cases in each group. The control group was treated with omeprazole enteric capsules,the study group was treated with rabeprazole sodium enteric- coated tablets. The clinical efficacy,helicobacter pylori clearance rate,adverse reactions and recurrence of the two groups were observed. Results The differences of the total effective rate and adverse reactions rate of two groups were not statistically significant( P > 0. 05). The helicobacter pylori clearance rate in the study group was higher than that in the control group,the long- term recurrence rate of the study group was lower than that of the control group,and the differences were statistically significant( P < 0. 05). Conclusion The clinical efficacy of rabeprazole in the treatment of helicobacter pylori correlation gastric ulcer is equivalent to omeprazole,it has less adverse reactions and lower long- term recurrence rate.
出处
《临床合理用药杂志》
2016年第12期3-4,7,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
胃溃疡
幽门螺杆菌
雷贝拉唑
治疗结果
Stomach ulcer
Helicobacter pylori
Rabeprazole
Treatment outcome
