摘要
目的:研究幽门螺杆菌(H.pylori)阳性胃溃疡患者根除H.pylori前后冒粘膜局部氧化应激反应的改变。方法:对72例 H.pylori阳性胃溃疡患者三联杀菌治疗前后的溃疡边缘粘膜组织行活性氧(ROS)、白细胞介素8(IL-8)含量及炎症积分测定。结果:在H.pylori根除后,胃粘膜ROS、IL-8含量及炎症积分均较根除前明显下降(P<0.001及P<0.01)。结论:根除 H.pylori可抑制致炎因子IL-8表达及减少ROS生成,从而降低胃溃疡粘膜局部氧化应激反应,减轻粘膜炎症,利于溃疡愈合。
To investigate the changes ofmucosa oxidatuve stress reaction after h pylori eradication in gastric ulcer patients methods ,72 cases of h pylori positive gastric ulcer patiemtas mucosa ROS il-8 content and inflammatory score were accessed before and after h pylori eradication treatmetn Results ROS il-8contentand inflammatory scorewere remarkably decreaaed after h pylori eradication which has statitiion of h pylori can boviously inhibite mucosa il-8 and ROS content which conseauently decreae oxidative stress reaction in the regional mucosa of gastric ulcer
