摘要
目的 研究活性氧 (reactiveoxygenspecies,ROS)在H .pylori相关性溃疡病发病中的作用及其与IL 8、炎症积分、cagA基因等的相关性。 方法 选择活动期消化性溃疡患者 10 0例 ,比较H .pylori阴性组及H .py lori cagA阳性组和H .pylori cagA阴性组 3组间的ROS及IL 8含量的差别。 结果 3组的ROS及IL 8分别为(5 6 .6 6± 4.5 0 )、(6 8.5 0± 6 .33)、(6 6 .33± 5 .0 0 )CI/mg及 [(12 .6 5± 3.47)、(2 7.37± 6 .32 )、(2 3.42± 8.0 7) ]×10 3 。后两组与第一组相比 ,ROS及IL 8含量差异显著 (P <0 .0 0 1) ,而后两组之间则无统计学差异。多元回归分析显示ROS与IL 8及炎症积分相关。结论 H .pylori感染可明显提高溃疡患者胃黏膜内的ROS含量 ,IL 8是ROS增高的首要相关因素。
Purpose: To demonstrate the role of ROS in the pathogenesis of H. pylori-associated peptic ulcer and clarify the correlation of ROS, IL-8, imflammatory score and cagA gene. Methods: Select 100 cases of active peptic ulcer patients and divide them into 3 groups as H. pylori negative, cagA positive H. pylori positive, cagA negative H. pylori positive. Then compare the IL-8 and ROS contents in them. Results: The ROS and IL-8 contents in the 3 groups result in (56.66 ± 4.50), (68.50 ± 6.33), (66.33 ± 5.00) CI/mg and [(12.65 ± 3.47), (27.37 ± 6.32), (23.42 ± 8.07)] × 103, respectively. There has a statistical significance between the H. pylori negative and the H. pylori positive (P0.75). The multiple linear regression analysis indicates IL-8 and inflammatory score are correlated with ROS level. The regression equation is constructed as ROS=52.05 + 0.39 (IL-8) + 0.28 (inflammatory score). Conclusions: H. pylori infection can obviously raise the ROS content in the regional mucosal of peptic ulcer. IL-8 and inflammatory score are the predominant factors for the elevation of ROS while cagA gene is not a valuable indicator for ROS content or mucosal inflammation level.
出处
《复旦学报（医学版）》
EI
CAS
CSCD
北大核心
2001年第3期236-238,共3页
Fudan University Journal of Medical Sciences
