摘要
目的 评价儿童流行性感冒人群中肺炎链球菌感染及耐药性 ,为临床提供准确可靠的诊疗依据。方法 选择儿科门诊流感伴呼吸道感染患者 2 93例 ,分别进行痰及咽拭子细菌培养 ,并进行青霉素G等 16种抗生素药物敏感试验 ,分析流感人群中肺炎链球菌的感染率、耐药率及 β 内酰胺酶产生率。结果 在 2 93份标本中 ,检出肺炎链球菌 5 1株 ,占 17.4 % ;除了对红霉素、克林霉素、四环素 10 0 %耐药 ,对其他抗生素均有不同程度的耐药 ,但万古霉素、头孢呋辛、利福平及呋喃妥因具有 10 0 %的敏感性 ;β 内酰胺酶产生率为 76 .5 %。结论 检出的 5 1株肺炎链球菌 ,对青霉素耐药率为 2 9.4 % ,中敏率达到 4 9.0 % ,提示存在耐药趋势 ,β 内酰胺酶产生株全部耐受青霉素G并具多重耐药。
OBJECTIVE To evaluate the state of Streptococcus pneumoniae infection in children with influenza,and to provide accurate and reliable basis for clinic. METHODS A total of 293 specimens of sputum and throat swabs collected from ill children with respiratory tract infection, which was performed germiculture and drug susceptibility tests to 16 antibiotics such as penicillin G, the infective rate, drug resistant rate and β-lactamases incidence of S. pneumoniae were analysed. RESULTS The identified rate of S. pneumoniae in 293 specimens was 17.4%(51/293); the resistant rate to erythromycin, clindamycin and tetracycline was 100% and it was found that these bacteria were also resistant to all the other agents in different degrees except susceptible to vancomycin, cefuroxime sodium, rifampicine and nitrofurantoin; the incidence of β-lactamases was 76.5%. CONCLUSIONS Among the 51 identified S. pneumoniae, the resistant rate to penicillin was 29.4%, the intermediate susceptibility was 49.0%, which suggested that drug resistant tendency be in existence; β-lactamases producing strains were all resistant to penicillin G and showed multidrug resistance; using drug according to experiences could not control the disease effectively, however, it would result in drug-resistance.
出处
《中华医院感染学杂志》
CAS
CSCD
2003年第6期591-592,共2页
Chinese Journal of Nosocomiology
关键词
流感
肺炎链球菌
耐药性
Influenza
Streptococcus pneumoniae
drug-resistance
