摘要
目的 :观察静脉滴注阿奇霉素治疗非淋菌性泌尿生殖道炎 (NGU )的临床效果。方法 :2 97例NGU病人 [男性 193例 ,女性 10 4例 ,年龄 (2 7±s8)a]分为 3组治疗。静脉滴注阿奇霉素组 (治疗组 )10 6例 ,用阿奇霉素粉针剂 0 .2 5 g加氯化钠注射液2 5 0mL ,iv ,gtt ,qd ;静脉滴注氧氟沙星组 (对照 1组 ) 73例 ,用氧氟沙星注射液 4 0 0mg加氯化钠注射液 2 5 0mL ,iv ,gtt ,qd ;口服阿奇霉素组 (对照 2组 )118例 ,用阿奇霉素片 0 .5 g ,po ,qd。 3组用药均首次加倍 ,疗程均为 7～ 10d。结果 :3组痊愈率分别为 80 .2 % ,6 0 % ,74 .6 % ,治疗组和对照 2组疗效差异无显著意义 (P >0 .0 5 ) ,并均高于对照 1组 (P<0 .0 5 )。结论 :2种阿奇霉素制剂治疗NGU效果均优于氧氟沙星 ,可作为目前治疗NGU的首选药物 ,静脉滴注阿奇霉素胃肠道反应较轻 。
AIM: To observe the clinical therapeutic effect of intravenous drip azithromycin in treating nongonococal urethritis (NGU). METHODS: Two hundred and ninety seven patients with NGU were divided into three groups. Intravenous drip azithromycin group (treatment group, n =106), was treated with azithromycin 0.25 g in sodium chloride injection 250 mL, iv, gtt, qd. Ofloxacin injection group (control group 1, n =73) was treated with ofloxacin injection 400 mg in sodium chloride injection 250 mL, iv, gtt, qd. Oral azithromycin group (control group 2, n =118) was treated with azithromycin tablets 0.5 g, po qd. Double doses were on the first time in three groups. The treating time were all 7-10 d. RESULTS: The cured rates of three groups were 80.2 %, 60 %, and 74.6 % . The therapeutic effects of treatment group and control group l were same ( P >0.05), and both were higher than that of control group 2 ( P <0.05). CONCLUSION: The therapeutic effect of two azithromycin preparations is better than that of ofloxacin in treating NGU, and all can be first selected to treat NGU at present. Intravenous drip azithromycin can be used for the patients who do not suit azithromycin tablets, because its alimentary tract adverse reaction is lower.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2003年第6期328-330,共3页
Chinese Journal of New Drugs and Clinical Remedies
