摘要
目的探讨硫酸镁和硝苯地平对妊娠期高血压疾病患者血清SFLT-1(血管内皮生长因子受体1)/PLGF(胎盘生长因子)的影响,明确硫酸镁和硝苯地平通过SFLT-1/PLGF影响妊娠期高血压疾病的作用机理。方法选取妊娠期高血压疾病患者130例分为:妊娠期高血压组52例(轻度高血压组33例,重度高血压组19例),子痫前期组60例,重度子痫前期组18例;并选取正常孕妇30例作为正常对照组(血压<140/90 mmHg,且孕期无蛋白尿)。使用硫酸镁和硝苯地平治疗,观察各组患者治疗前后血压变化,采用ELISA法检测治疗前后PLGF、SFLT-1的表达。结果用硫酸镁和硝苯地平治疗后,平均动脉压较治疗前显着降低(P<0.05)。PLGF在妊娠期高血压疾病中较正常对照组显著降低(P<0.05),经硫酸镁和硝苯地平治疗后PLGF显著升高(P<0.05);SFLT-1在妊娠期高血压疾病中较正常对照组显著升高(P<0.05),经硫酸镁和硝苯地平治疗后显著降低(P<0.05)。SFLT-1/PLGF比例在妊娠期高血压疾病中具有逐渐升高的趋势,特别是在子痫前期中较正常对照组及妊娠期高血压患者升高显著(P<0.05);硫酸镁硝苯地平治疗后(T-sFLT-1/PLGF)较治疗前降低(P<0.05),特别是在子痫前期中较正常对照组及妊娠期高血压患者降低明显(P<0.05)。相关性分析发现PLGF与SFLT-1呈负相关性。结论 PLGF、SFLT-1均参与调节了妊娠期高血压疾病的进展,SFLT-1/PLGF在子痫前期-子痫发展中发挥重要作用,PLGF、SFLT-1在妊娠期高血压疾病中存在负相关性,调控不同因子的表达可能在妊娠期高血压疾病的预防及治疗中发挥作用;硫酸镁和硝苯地平能调节妊娠期高血压疾病PLGF、SFLT-1的表达水平。
Objective To investigate the effects of magnesium sulfate and nifedipine on serum SFLT-1(vascular endothelial growth factor receptor 1)/PLGF(placental growth factor)in patients with pregnancy-induced hypertension and clarify the mechanism of magnesium sulfate and nifedipine on pregnancy-induced hypertension through SFLT-1/PLGF.Methods 130 patients with hypertensive disorder in pregnancy were selected and divided into 5 group:52 cases of gestational hypertension(33 patients with mild hypertension,19 patients with severe hypertension),60 patients with pre-eclampsia,and 18 patients with severe pre-eclampsia.30 cases of normal pregnant women were selected as normal control group(blood pressure<140/90 mmHg,and no proteinuria during pregnancy).The patients were treated with magnesium sulfate and nifedipine.The changes of blood pressure before and after treatment were observed.The expressions of PLGF and SFLT-1 were detected by ELISA.Results After treatment with magnesium sulfate and nifedipine,the mean arterial pressure was significantly lower than that before treatment(P<0.05).PLGF in pregnant with hypertensive disorder was significantly lower than that in normal pregnant women(P<0.05),and PLGF was significantly increased after magnesium sulfate and nifedipine treatment(P<0.05).SFLT-1 was significantly higher in hypertensive disorder complicating pregnancy than that in normal pregnant women(P<0.05)and significantly decreased after treatment with magnesium sulfate and nifedipine(P<0.05).The rate of sFLT-1/PLGF in hypertensive disorders of pregnancy tends to increase gradually,especially in pre-eclampsia,which was significantly higher than that in normal and hypertensive patients of pregnancy(P<0.05).The ratio of T-sFLT-1/PLGF after treatment with magnesium sulphate nifedipine was lower than that before treatment(P<0.05),especially in pre-eclampsia,which was significantly lower than that in normal and gestational hypertension patients(P<0.05).The correlation analysis showed that PLGF was negatively correlated with SFLT-
作者
郭莉
李彩霞
马宇凌
GUO Li;LI Cai-xia;MA Yuling(Wu Zhong People's Hospital of Ningxia,Wu Zhong 751100,China)
出处
《宁夏医学杂志》
CAS
2019年第6期497-500,共4页
Ningxia Medical Journal
