摘要
目的:探索南京市鼓楼区居民胆囊疾病与胰岛素抵抗、胰岛β细胞功能的关系以及胆囊疾病患者的糖尿病发生风险。方法:对南京市鼓楼区8 180例既往无糖尿病的居民进行问卷调查、体格检查、血样采集、口服糖耐量试验(OGTT)及胰岛素释放试验。分析胆囊疾病各组的特征,比较各组胰岛素抵抗与胰岛β细胞功能指标,分析胆囊疾病患者糖尿病风险。结果:性别、年龄、血压、体重指数(BMI)、腰臀比(WHR)、负荷后血糖、糖化血红蛋白(Hb A1c)、血脂、肝酶、生活方式及糖尿病发病率在无胆囊疾病、胆囊疾病未手术及胆囊疾病术后3组的分布不同。2组胆囊疾病患者胰岛素敏感性指标胰岛素抵抗(HOMA-IR)、胰岛素敏感指数(ISI)、胰岛素释放指数(INSR120)与无胆囊疾病者的差异有统计学意义(P<0.05)。胆囊疾病手术后糖尿病及代谢综合征风险增加。结论:胆囊疾病在既往无糖尿病史的南京市鼓楼区居民中是胰岛素抵抗的标志,胆囊疾病术后状态是糖尿病的危险因素。
Objective:To investigate the relationship of gall bladder diseases with insulin resistance(IR) and islet β cell function in people living in Gulou District,Nanjing. Methods:Questionnaire survey,physical examination,blood sample collection,OGTT and insulin release test were performed in 8 180 non-diabetic residents in Gulou district,Nanjing. We analyzed characteristics of different gall bladder-disease stages,compared IR and islet β cell function indexes and focus on the risk of diabetes in patients suffering from gall bladder diseases. Results:Gender,age,blood pressure,BMI,WHR,OGTT results,Hb A1 c,blood lipids,liver enzymes,life styles and incidence of diabetes showed differences in three groups. HOMA-IR,ISI and INSR120 differ in two gall bladder disease groups and the differences were statistical significant(P < 0.05). Post-cholecystectomy represents higher risk of diabetes as well as metabolic syndrome(MS). Conclusion:Gall bladder diseases are signs of IR. Post-cholecystectomy is a risk factor of diabetes in non-diabetic residents in Gulou District,Nanjing.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2015年第8期1114-1117,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家代谢性疾病临床医学研究中心项目(2013BAI09B13)
科技部重大新药创制项目(2012ZX09303006-001)
关键词
胆囊疾病
胰岛素抵抗
胰岛Β细胞功能
糖尿病风险
gall bladder disease
insulin resistant
islet β cell function
risk of diabetes
