摘要
通过测定高血压病患者的血糖、血脂、血清胰岛素和C肽,计算胰岛素释放指数及胰岛素敏感指数,对照分析发现两组的血糖、C肽值无显著差异,而高血压病组的血清胰岛素及胰岛素释放指数较对照组显著增高(t=2.6621,2.5532,P<0.01),胰岛素敏感指数则显著降低(t=1.9028,P<0.05)。这提示高血压病患者体内存在高胰岛素血症和胰岛素抵抗。其发生原因与组织对胰岛素的敏感性降低、胰岛素分泌异常增多以及胰岛素经肝脏降解减少有关,后者很可能伴有C肽经肾脏排泄增多。
Blood glucose (BS), .lipid, insulin (IS) and C-peptide (CP) were measured and the insulinogenic index and insulin sensitive index were calculated in 66 essential hypertension patients and 23 normotensive subjects. The patients showed a higher fasting serum insulinogenic index (P<0.01) and a lower insulin sensitive index (P<0.05). The BS and CP levels of Patients were respectively similar with those of normotensives. These results strongly suggest that there were hyperinsulinemia and insulin resistance (IR) in essential hypertensive patients. The hyperinsulinemia and IR may be caused by a beta-cell hypersecretory response to the defective Peripheral sensitivity of insulin and by a decreased hepatic IS clearance with possibly increased urinary CP excretion.
出处
《天津医药》
CAS
1994年第9期536-538,共3页
Tianjin Medical Journal
