摘要
电离辐射可以改变细胞色素P-450(主要有CYP1B1、CYP1A1、CYP4A11、CYP2E1等)的活性和(或)mRNA、蛋白含量,从而影响药物代谢和有毒化学物的生物转化过程及其生物学作用。细胞色素P-450参与了生物还原活性物TMQ、AQ4N在机体内的还原。动物实验和已有的临床研究表明,调节P-450可以提高生物还原活性物的辐射增敏作用和抗肿瘤作用。
Ionizing radiation can change the activity and/or the expression of mRNA,protein of Cytochrome P-450(CYP1B1,1A1,4A11,2E1),consequently influence the biotransformation and biological effects of the drugs and toxi-coid metabolization.Cytochrome P-450participated in the reduction of bioreductive drugs(including TMQ,AQ4N).Ani-mal experiments and clinical trials show Cytochrome P-450can be taken advantage to exert well sensitization for radio-therapy and chemotherapy.
出处
《国外医学（放射医学核医学分册）》
2003年第2期77-79,83,共4页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金
国家自然科学基金资助项目(编号:30100042)
