摘要
在探讨维生素 E的抗氧化作用机制的基础上 ,结合 FAB-MS谱中 M+· 的形成过程 ,对 FAB-MS法与药物抗氧化作用的相关性进行了研究 ,利用循环伏安法测定氧化峰电位 ,并进行比较。研究表明 :FAB-MS谱中 M+· 峰的相对强度在一定程度上可以反映化合物的抗氧化作用强弱 。
Based on the antioxidant mechanism of α-tocopherol and the formation process of molecular ion M +· under FAB conditions, the relationship between the FAB-MS and antioxidative effect is discussed,and it is found that they all involve a one-electron transfer. Cyclic Voltammogram (CV) is carried out to get the oxidation potentials (Epa) which can reflect the antioxidative effect of compounds. Furthermore, the ratios of I(M +·)/I( +) evaluated from the FAB-MS spectra are correlated with the Epa, the ratios are higher, the Epa are lower. Therefore, it is demonstrates that the intensity of M +· in FAB-MS spectra can reflect the antioxidative effect of compounds to some extend, FAB-MS techniques can provide a useful clue to screen the antioxidative activity of compounds.
出处
《质谱学报》
EI
CAS
CSCD
2003年第2期346-350,共5页
Journal of Chinese Mass Spectrometry Society
