摘要
目的 探讨中枢神经系统 (CNS)脂肪瘤的临床病理特征、影像学、组织发生学、治疗及预后。方法 对我院 1 983— 2 0 0 0年间 4386例CNS肿瘤中 1 1例CNS脂肪瘤 (0 2 5 % )进行临床病理观察。结果 本组患者年龄 1 1个月～ 59岁 ,平均 2 6 6岁。肿瘤发生于颅内 5例 (胼胝体 4例 ,鞍区 1例 ) ,椎管内 5例 ,颅、椎管内 1例。其中 3例合并先天性畸形 ,包括先天性颅裂伴脑膜膨出、胼胝体缺如及额正中皮下脂肪瘤 ;胼胝体发育不良 ;先天性骶椎脊柱裂伴脊膜膨出以及腰骶正中皮下脂肪瘤。光镜下 ,由不同比例的脂肪、血管、纤维和神经组织混合而成 ,甚至可见横纹肌组织 ,并可见砂砾体及裹入的神经根组织。随访 9例 ,8例术后生存 1～ 1 2 4年。结论 CNS脂肪瘤属于先天性畸形 ,中线附近多发。除了活检外 ,还可通过MRI和CT检查诊断。术后患者预后良好。肿瘤的组织发生学尚不清楚。
Objective To investigate clinicopathological features, im aging, histogenesis, treatment and prognosis of central nervous system (CNS) lip omas Methods Totally 11 patients of CNS lipomas from 1983-2 000 were reviewed in this study Results In all of cases, age ranged from 11 months to 59 year s (average 26 6 years) with 5 tumors localized in the intracranial cavity, 5 in the intraspinal cavity, and 1 in the intracranial-intraspinal cavity Three c ases were associated with congenital anomalies In the 9 patients with follow- up data, 8 survived for 1～12.4 years after operation (average 50.7 months) Th ere were fat cells, blood vessels, fibrous and nervous tissues in the tumors Conclusions CNS lipomas are congenital malformation and tend to arise near the midline The diagnosis can now be made reliably without biops y by MRI and CT The prognosis of the most patients is usually favorable after operation The exact histogenesis of the tumors is unclear
出处
《诊断病理学杂志》
CSCD
2003年第2期88-90,T026,共4页
Chinese Journal of Diagnostic Pathology
