摘要
目的 :检测狼疮肾炎 (LN)患者外周血清和尿液白细胞介素 - 18(IL - 18)水平并探讨其临床意义。方法 :血清和尿液IL - 18含量采用酶联免疫吸附方法 (ELISA)。结果 :LN组血清IL - 18水平显著高于正常对照组 (P<0 .0 1) ,活动期LN血清IL - 18水平显著高于缓解期患者 (P <0 .0 1) ;LN组尿IL - 18水平显著高于正常对照组 (P<0 .0 5 ) ,活动期LN患者尿IL - 18水平显著高于缓解期患者 (P <0 .0 5 )。LN患者血清IL - 18水平与SLEDAI、抗dsDNA抗体成正相关关系 ,与补体C3 呈负相关关系 ,而与血白蛋白、血肌酐无相关关系 ;活动期LN患者尿IL - 18水平与狼疮肾组织活动性指数 (AI)、2 4h尿蛋白排泄量均呈正相关关系。结论 :LN血清和尿IL - 18水平显著增高 ,IL- 18可能在LN的病理生理过程中起重要作用。LN血清和尿IL - 18水平均与狼疮病情活动密切相关 。
Objective:To detect serum and urine interleukin-18 concentrations in patients with lupus nephritis(LN) and investigate their clinical significance.Methods:Interleukin-18 concentrations were measured by enzyme-linked immunosorbent assay(ELISA).Results:Serum and urine IL-18 concentrations were significantly higher in LN patients than those in control subjects.Serum and urine IL-18 concentrations increased in active LN patients when compared with inactive patients .Increases in serum IL-18 concentrations correlated positively and significantly with SLEDAI score and anti-dsDNA antibody. Elevations of urine IL-18 concentrations have an positive correlation with lupus kidney active index(AI)score and 24 h urine protein excretion,respectively.Conclusion:The novel cytokine IL-18 might play an important role in the inflammatory processes in LN.Serum or urine IL-18 concentrations may be use an predictor of disease activity in LN.
出处
《中国中西医结合肾病杂志》
2003年第4期212-214,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
