摘要
目的:探讨血清β_2-微球蛋白及血清Ⅲ型前胶原含量与肝炎临床病理变化的关系。方法:对110例急、慢性肝炎及肝炎后肝硬化患者行肝活检,病理变化用Knodell组织学活动指数(HAI)标准记分判定,同时用RIA法测定血清β_2-微球蛋白(β_2-M)及血清Ⅲ型前胶原(PCⅢ)含量,将组织学变化与血清学指标进行相关分析。结果:血清β_2-M含量与肝细胞坏死范围及炎性细胞浸润程度相关(r=0.670,P<0.01),血清PCⅢ含量与肝纤维化程度相关(r=0.668,P<0.01)。结论:血清β_2-M和PCⅢ含量变化分别是反映肝实质炎症活动程度和肝纤维化程度的有价值指标。
Aim: To study the relationship between the clinicopathology of hepatitis and serum BBBBBB2-microglo-bulin (βb2-M) and serum procollagen type Ⅲ (PCⅢ ). Methods: The serum β2-M and PC Ⅲ of 110 patients with acute and chronic hepatitis, and posthepatitic liver cirrhosis was determined by RIA kit. Clinicopathology of hepatitis was scored in Knodell's Histological Activity Index (HAD). Results: The serum β2-M and PC Ⅲ levels of patients with acute and chronic hepatitis, and post-hepatitis liver cirrhosis well all significantly higher than that of normal controls (P<0. 05-0. 01). The levels of serum β2-M were positively correlated to the range of necrosis of hepatocyte and the degree of inflamation of portal area (r = 0. 670. P<0. 01). The levels of serum PCⅢ were positively correlated to the degree of hepatic fibrosis (r = 0. 668, P<0. 01). Conclussions: The determination of β2-M is a useful index for diagnosis of liver parenchymatitis. Serum PC Ⅲ is a useful index of hepatic fibrosis.
出处
《中西医结合肝病杂志》
CAS
1998年第1期4-6,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
Β2-M
病毒性肝炎
肝活检
组织活动性指数
Viral Hepatitis β2-microglobulin Procollagen Type Ⅲ Liver Biopsy Histological Activity Index
