摘要
目的:探讨痰气交阻型胃食管反流病(GERD)应用代赭旋覆汤治疗的临床效果。方法:选取2016年3月—2018年3月我院收治的98例GERD患者,根据随机数字表法将这98例患者随机分成观察组与对照组,各49例。对照组予以常规西药(雷贝拉唑+莫沙必利)治疗,观察组在此基础上联合代赭旋覆汤治疗。所有患者均治疗8周。比较两组临床疗效,治疗前后食管压力参数[上、下食管括约肌静息压(UESP和LESP)、远端收缩积分(DCI)]、心理状态相关量表[焦虑自评量表(SAS)、汉密顿抑郁量表17项(HAMD-17)]评分和GERD生存质量量表(GERDQOL)评分变化,不良反应发生情况。结果:观察组总有效率为93.9%(46/49),明显高于对照组[79.6%(39/49)],P<0.05。两组治疗后UESP、LESP及DCI值较治疗前均显著增加(P<0.05),且观察组升高更显著(P<0.05)。与治疗前对比,两组治疗后SAS、HAMD-17评分均显著降低(P<0.05),GERD-QOL中日常活动、心理健康维度评分及总分均显著增高(P<0.05);且观察组改善更显著(P<0.05)。观察组不良反应率[6.1%(3/49)]较对照组[4.1%(2/49)],差异无统计学意义(P>0.05)。结论:痰气交阻型GERD应用代赭旋覆汤治疗可明显减轻患者症状,改善食管运动功能,调整心理状态,提高生活质量,疗效确切,患者耐受性较高。
Objective:To explore the clinical efficacy of Daizhe Xuanfu Decoction on phlegm-Qi obstruction type gastroesophaeal reflux disease(GERD). Methods:98 patients with GERD admitted in our hospital from March 2016 to March 2018,were randomly divided into observation group(n=49)and control group(n=49)according to random number table method. The control group was treated with conventional Western medicine(rabeprazole + mosapride),the observation group was given the treatment of Daizhe Xuanfu Decoction on the basis of the control group. All patients were treated for 8 weeks. The clinical efficacy,changes of esophageal pressure indexes [upper/lower esophageal sphincter pressure(UESP and LESP),distal contractile integral(DCI)] and mental state related scale scores [self-rating anxiety scale(SAS),hamiden depression scale 17 items(HAMD-17)] as well as GERD quality of life salce(GERD-QOL)scores before and after treatment,and adverse reactions were compared between the two groups. Results:The total effective rate of the observation group was 93.9%(46/49),was much higher than 79.6%(39/49)of the control group(P<0.05). After treatment the UESP,LESP and DCI of both groups increased remarkably compared with those before treatment(P<0.05),and the increase of the observation group was more significant(P<0.05). Compared with before treatment,the SAS and HAMD-17 scores were significantly lower after treatment(P<0.05). The daily activities,mental health dimension scores and total scores of GERD-QOL were significantly increased(P<0.05);and the improvement of the observation group was more significant(P<0.05). The adverse reaction rate of the observation group [6.1%(3/49)] was lower than that of the control group [4.1%(2/49)],and the difference was not statistically significant(P>0.05). Conclusion:The application of Daizhe Xuanfu Decoction in the treatment of phlegmQi obstruction type GERD can significantly alleviate the symptoms of patients,improve the function of esophageal motor,adjust the psychological state,improve the quality of lif
作者
马万援
MA Wanyuan(Qinghai Hospital of Traditional Chinese Medicine,Xining 810000,Qinghai,China)
出处
《辽宁中医药大学学报》
CAS
2019年第4期200-203,共4页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
胃食管反流病
痰气交阻型
代赭旋覆汤
食道压力
心理状态
生活质量
gastroesophaeal reflux disease
phlegm-Qi obstruction type
Daizhe Xuanfu Decoction
esophageal pressure
mental state
life quality