摘要
阿尔茨海默病(Alzheimer's disease,AD)是临床上常见的慢性神经退行性疾病,可引起语言、行为等认知障碍,截止目前其发病机制仍不十分清楚。micro RNA(mi RNA)作为AD新型的生物标志物,是近年的研究热点。目前的研究显示,mi R-125b、mi R-223、mi R-342-3p、mi R-34c、mi R-384等可能是潜在的AD诊断标志物,而且多种mi RNA的联合检测也可作为AD诊断标志物,但目前尚无多种mi RNA联合检测与单个mi RNA检测效果的比较研究。本文旨在对mi RNA检测对AD早期诊断作用的研究进行综述。
Alzheimer's disease (AD) is a complicated progressive neurodegenerative disease leading to dementia including language and behavior, and its pathogenesis is still unknown. MicroRNA(miRNA)are recently focused on as novel biomarkers for AD patients. 16 eligible studies of circulating miRNA in AD detection were identiifed through PubMed, suggested that circulating miRNA (miR-125b,miR-223,miR-342-3p,miR-34c and miR-384,et al) may be potential, none-invasive and novel biomarkers of AD. Furthermore, the combination of some miRNA are also applied for AD diagnosis, but no studies report the comparision between single miRNA and miRNA signature for AD detection.
出处
《中华老年病研究电子杂志》
2016年第1期26-29,共4页
Chinese Journal of Geriatrics Research(Electronic Edition)
