摘要
目的研究多西他赛联合顺铂及替吉奥在局部晚期鼻咽癌中的近期临床疗效及安全性。方法选取2016年2月-2018年2月我院收治的94例局部晚期鼻咽癌患者为研究对象,以随机法均分成观察组与对照组。对照组诱导化疗方案为多西他赛联合顺铂及氟尿嘧啶,观察组诱导化疗方案为多西他赛联合顺铂及替吉奥。比较两组患者的近期临床疗效、治疗前后免疫功能、毒副反应发生情况。结果观察组近期总有效率显著高于对照组(P<0.05)。治疗后观察组血清IL-12、IFN-γ水平显著高于对照组,而血清MMP-2水平显著低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论多西他赛联合顺铂及替吉奥诱导化疗对局部晚期鼻咽癌患者的近期临床疗效显著,可改善免疫功能,且不增加不良反应。
Objective To investigate the short-term clinical efficacy and safety of docetaxel combined with cisplatin and S-1 for locally advanced nasopharynx cancer.Methods A total of 94 patients with locally advanced nasopharynx cancer admitted to our hospital between February 2016 and February 2018 were selected as subjects,and they were randomly divided into the observation group and control group.The control group was treated with docetaxel combined with cisplatin and fluorouracil,while the observation group was treated with docetaxel combined with cisplatin and S-1.The differences were compared between the two groups in clinical short-term efficacy,immune function before and after treatment,and toxic and side effects.Results The short-term total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of serum IL-12 and IFN-γwere higher in the observation group than in the control group,while the levels of serum MMP-2 were lower in the observation group than in the control group(all P<0.05).No significant differences were found between the observation group and the control group in the incidences of gastrointestinal response,peripheral nerve damage,liver and kidney dysfunction,bone marrow suppression and leukopenia(all P>0.05).Conclusion Docetaxel combined with cisplatin and S-1 had significant short-term clinical efficacy in the treatment of locally advanced nasopharynx cancer.It could help improve the immune function of patients without increasing the incidence of toxic side effects.So it is safe and worthy of clinical application.
作者
刘林
肖锋
张琳
何倩
李云
周钰娟
刘峰
LIU Lin;XIAO Feng;ZHANG Lin;HE Qian;LI Yun;ZHOU Yujuan;LIU Feng(The Head and Neck Radiotherapy Department,Hunan Cancer Hospital,the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,Hunan,410013,China)
出处
《肿瘤药学》
CAS
2019年第1期72-75,共4页
Anti-Tumor Pharmacy
基金
湖南省自然科学基金(2016JJ6088)
中国癌症基金会北京希望马拉松专项基金(LC2016W05)
关键词
局部晚期鼻咽癌
多西他赛
顺铂
替吉奥
不良反应
Local advanced nasopharynx cancer
Docetaxel
Cisplatin
S-1
Adverse reactions
