摘要
目的 :评估氟西汀对阻塞型睡眠呼吸暂停低通气综合征 (OSAHS)的治疗反应。方法 :10例经多导睡眠图 (PSG)诊断的OSAHS患者 ,进行Epworth嗜睡量表 (ESS)评估后 ,开始应用氟西汀 (每日 2 0mg口服 )治疗 ,4wk后重复检查PSG及ESS。用配对t检验方法进行统计处理。结果 :氟西汀治疗 4wk后 ,患者REM睡眠比例平均减少 9.2 % ,ESS评估平均降低 2分 ,有显著的统计学意义 (P <0 .0 1) ,睡眠潜伏期无明显变化 (P >0 .0 5 ) ;睡眠呼吸暂停及低通气指数 (AHI)平均下降 2 4 .8·h-1,平均血氧饱和度和最低血氧饱和度分别升高 3.2 %、16.6% ,氧减饱和指数平均下降 18.2·h-1(P <0 .0 1) ,平均暂停时间无统计学意义 (P >0 .0 5 ) ;5例AHI下降超过一半 ,治疗有效率为 5 0 %。结论 :OSAHS患者短期服用氟西汀可部分改善睡眠质量和缺氧状况 。
AIM: To evaluate the response of obstructive sleep apnea hypopnea syndrome (OSAHS) to fluoxetine. METHODS: After a baseline polysomnography (PSG) and Epworth Sleepiness Scale (ESS) documented OSAHS, 10 patients were treated with fluoxetine (20 mg·d -1 ) for four weeks, a repeating PSG and ESS was performed to evaluate the action of fluoxetine. RESULTS: After 4 weeks fluoxetine treatment, the proportion of REM sleep time was decreased by 9.2 %, and the assessment of ESS was significantly decreased (P< 0.01 ). The differences in sleep latency were not statistically significance (P> 0.05 ). The apnea/hypopnea index (AHI) fell in average 24.84 per hour,the mean SaO 2 and minimum SaO 2 significantly increased by 3.2 % and 16.6 %, respectively, and desaturation event index significantly decreased 18.24 per hour (P< 0.01 ). The mean duration of apnea had no statistically significant differences (P> 0.05 ). The treatment efficiency of fluoxetine to OSAHS was 50%. CONCLUSION: Short term use of fluoxetine in patients with OSAHS is associated with better sleep quality, improvement in oxygenation,and reduction of episodic apneas or hypopneas.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第2期133-135,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
