摘要
目的：观察温胆汤联合无创呼吸机对重度阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者临床症状、呼吸暂停次数、最长呼吸暂停时间，低通气次数、平均指端血氧饱和度（MSpO2）、最低指端血氧饱和度（LSp02）和血清瘦素（1eptin）的影响。方法：选择经多导睡眠图（PSG）确诊的重度OSAHS患者50例，随机分为治疗组25例和对照组25例，治疗组用温胆汤联合无创呼吸机治疗，温胆汤每日一剂，每服28剂为1疗程，无创呼吸机每天治疗8～14h，共同治疗3个月，而对照组则单用无创呼吸机治疗。两组均于治疗前及治疗后1月、2月、3月进行临床症状评分、睡眠监测及检测血清瘦素水平，比较治疗前后各项指标的差异。结果：治疗组经温胆汤联合无创呼吸机治疗3个月后，呼吸暂停次数与低通气次数明显降低，MSpO2和LSpO2显著升高，且血瘦素水平较治疗前显著降低。而且与对照组相比，治疗组临床症状明显改善，呼吸暂停次数、低通气次数及血瘦素水平都有明显的降低。相关性分析表明，0SAHS患者血瘦素与呼吸暂停次数、低通气次数呈正相关。结论：温胆汤联合无创呼吸机治疗能够显著降低重度OSAHS患者血瘦素水平，进而降低呼吸暂停次数和低通气次数，从而改善OSAHS患者的预后。
AIM： To observe the impact of wendantang combined non-invasive ventilation on the number of clinical symptoms, apnea, the longest apnea time, the number of low hypopnea, average oxygen saturation finger, lowest oxygen saturation finger and leptin in the patients of severe OSAHS. METHODS： Total 50 severe cases of OSAHS as test group were chosen, and divided into treatment group and con- trol group randomly, that was to say 25 cases each group. The treatment group peros wendan- tang day one of each serving 28 for a course, combined non-invasive positive pressure ventilation therapy 8-14 hours a day, while the control group used noninvasive ventilation only. Then the level of sleep monitoring indicators and leptin by polysomnography and radio-immunity assay was tested to compare the changes of these indexes before and after the treatment in one month, two months and three months. RE- SULTS： The level of the number of apnea, the number of low hypopnea, leptin obviously decreased while the level of average oxygen saturation finger, lowest oxygen saturation finger significantly increased by taking wendantang conlbined noninvasive ventilation in treatment group after three months. Moreover, the level of the clinical symptoms and the number of apraea, the number of low hypopnea, leptin obviously decreased as compared with the control group. The relative analysis indicated that the level of the number of apnea, the number of low hypopnea in the patients of severe OSAHS had positive correlation with leptin. CONCLUSION： Wendantang combined noninvasive ventilation can cut down the level of leptin in the patients of severe cases OSAHS obviously, thereby reducing the number of apnea and low hypopnea , and improve the prognosis in the patients of OSAHS accordingly.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2014年第6期686-690,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
