摘要
目的:为给临床提供诊断阿尔茨海默病(Alzheimer's disease,AD)的客观指标,采用ELISAs法分析了21例AD、28例非AD痴呆、35例其它神经系统疾病患者、50例正常对照者脑脊液标本,观察正常老化和AD进程中脑脊液中Tau、Aβ1～40、Aβ1～42/43变化规律。结果:Tau水平随年龄而增加,AD组Tau水平为(491.5±35.7)ng/L且与临床进程存在相关性,Aβ1～42/43水平为(109.9±73.2)pmol/L,Aβ1～40、Aβ1～42/43为(16.03±4.07)。AD组Tau水平、Aβ1～40/Aβ1～42/43比率显著高于其组及Aβ1～42/43水平低于其他组的结果说明对CSF中Tau、Aβ1～40、Aβ1～42/43的分析可以帮助诊断AD。
Objective: Alteration of protein markers in the CSF of Alzheimer's disease. To provide a objective marker for clinic diagnosis of Alzheimer's disease. Methods: 134 CSFsamples (21 of AD, 28 of Non -AD, 35 of other neurologic diseases, 50 of normal control)were analyzed by sensitive enzyme-linked immunosorbent assays for alterations of Tau, amyloid-β protein 1-42. Results: A significant elevation of tau and a correlation between the tau levels and the clinical progression were observed in the Aβ-42(43) levels and a signigicant increase of the ratio of Aβ1-Aoto Aβ1-42 (43) were observed in the AD patients. A significant deerease of the Aβ-42(43)levels and a signigicant increase of the ratio of Aβ-Aoto Aβ1-42(43) were observied in the AD patients. Conclusion: The Analysis of Tau, Aβ1-40, Aβ1-42 (43), Aβ1- 40/Aβ1 -42(43)in CSF of AD patients may help the clinic diagnosis of Alzheimer's disease.
出处
《脑与神经疾病杂志》
2003年第1期11-13,共3页
Journal of Brain and Nervous Diseases
