摘要
目的 探讨氨茶碱和肾上腺素联合应用在心脏停搏患者中的疗效是否优于单纯使用肾上腺素。方法 2 4例心跳骤停患者给予氨茶碱和肾上腺素联合用药 ,30例心跳骤停患者单用肾上腺素作为对照组。比较 2组患者的心脏电活动和自主循环恢复情况以及存活率。结果 ①合用组 19例 (79 2 % )患者恢复心电活动 ,高于肾上腺素组 5 3 3% (16 /30 ) ,差异接近显著 (P =0 0 82 )。②合用组 1、3、6h的生存率分别为 87 5 % (2 1/2 4 )、5 4 2 % (13/2 4 )和 37 5 % (9/2 4 ) ,亦分别高于肾上腺素组 (1h 5 6 7% ;3h 2 0 % ;6h 13 3% ) ,差异亦具有显著意义 (P <0 0 5 )。③合用组有 12例 (5 0 0 % )患者恢复自主循环 ,也高于肾上腺素组 (40 0 % ,12 /30 ) ,但差异不显著 (P =0 4 6 2 )。④合用组有 2例 (8 3% )患者出院 ,高于肾上腺素组 (3 3% ,1/30 ) ,差异不显著 (P =0 5 79)。结论 氨茶碱与肾上腺素联合用药在心脏停搏患者中的疗效可能优于单纯使用肾上腺素。
Objective To determine whether aminophylline associating with epinephrine has more beneficial effect than epinephrine on the victims of cardiac arrest. Methods Cardiac electrical activity, spontaneous circulation and survival rate of 24 patients received intravenous epinephrine and aminophylline compared with those of 30 cases received only epinephrine. Results ①There were 19(79.2%) cases who recovered cardiac electrical activity in the group with aminophylline, and 6(53.3%) in only epinephrine group. The difference was marginally significant (P=0.082).②The survival rate of 1 h(87.5%), 3 h(54.2%) and 6 h(37.5%) in the group with aminophylline were significantly higher than that of 1 h 56.7%, 3 h 20.0% and 6 h 13.3% in only epinephrine group respectively ( P <0.05). ③There were 12 cases (50.0%) who recovered spontaneous circulation in the group with aminophylline, which were higher than in only epinephrine group (40%). The difference was not statistically significant (P=0.462).④There were 2 cases (8.3%, 2/24) who discharged in the group with aminophylline, which was higher than in only epinephrine group (3.3%, 1/30). The difference was also not statistically significant (P=0.579). Conclusion These results suggested that aminophylline associating with epinephrine on the treatment of cardiac arrest might be better than only epinephrine.
出处
《中国急救医学》
CAS
CSCD
北大核心
2003年第4期232-233,共2页
Chinese Journal of Critical Care Medicine
基金
解放军总医院院长基金项目 (2 0 0 2 -1)
