摘要
目的探讨血清总胆红素(TBIL)、糖化白蛋白(GA)、糖化血红蛋白(Hb A1c)与糖尿病血管并发症的关系。方法选取糖尿病患者176例,根据是否有血管并发症分为血管病变组和无血管病变组。测定两组TBIL、GA、Hb A1c等生物化学指标。采用Logistic二元回归分析糖尿病患者血管并发症的影响因素。结果最终纳入血管病变组的有120例,纳入无血管病变组的有56例。两组性别、年龄、体质指数(BMI)比较差异无统计学意义(P>0. 05)。与无血管病变组比较,血管病变组患者的病程更长,总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、TBIL数值更低,GA、Hb A1c、甘油三酯(TG)和低密度脂蛋白胆固醇(LDLC)数值更高,差异具有统计学意义(P<0. 05);进一步二元Logistic回归分析结果显示,Hb A1c水平高、TBIL水平低和病程长是糖尿病血管并发症的独立危险因素(P<0. 05)。结论临床应积极关注糖尿病患者的Hb A1c和TBIL水平,注意血管病变的筛查并积极干预,避免严重并发症的发生。
Aim To investigate the relationship between serum total bilirubin(TBIL),glycated albumin(GA),hemoglobin A1 c(Hb A1 c)and diabetic vascular complications.Methods 176 diabetic patients hospitalized in our hospital from August 2017 to May 2018 were divided into vascular disease group and non-vascular disease group according to whether there were vascular complications.Biochemical indexes such as TBIL,GA and Hb A1 c were measured.Logistic binary regression was used to analyze the influencing factors of vascular complications in patients with diabetes mellitus.Results 120 cases were eventually included in vascular disease group and 56 cases in the non-vascular disease group.There was no significant difference in gender,age and body mass index(BMI)between the two groups(P>0.05).Compared with non-vascular disease group,vascular disease group had longer course of disease,lower values of total cholesterol(TC),high density lipoprotein cholesterol(HDLC)and TBIL,higher values of GA,Hb A1 c,triglyceride(TG)and low density lipoprotein cholesterol(LDLC),the difference was statistically significant(P<0.05).Further binary logistic regression analysis showed that high Hb A1 c level,low TBIL level and long course of disease were independent risk factors for diabetic vascular complications(P<0.05).Conclusion The screening of vascular diseases and active intervention should be paid to avoid the occurrence of serious complications.
作者
左红
王述进
冯佳
刘旭峰
杨华
ZUO Hong;WANG Shujin;FENG Jia;LIU Xufeng;YANG Hua(Xi'an Ninth Hospital,Xi'an,Shaanxi 710054,China)
出处
《中国动脉硬化杂志》
CAS
2019年第9期787-790,共4页
Chinese Journal of Arteriosclerosis
关键词
糖尿病
血管并发症
糖化白蛋白
糖化血红蛋白
总胆红素
diabetes mellitus
vascular complications
glycosylated albumin
glycosylated hemoglobin
total bilirubin
