摘要
目的探讨2型糖尿病患者血浆脂肪细胞因子Apelin-12水平变化及其与血糖的关系。方法选取2012年1月至2015年6月在民航总医院内分泌科住院的41例2型糖尿病患者作为研究对象,并招募44例健康对照者作为对照组。根据有无合并冠心病、脑血管病及高血压病将2型糖尿病患者再分为2型糖尿病合并心脑血管疾病组(21例)和单纯糖尿病组(20例)。酶联免疫吸附法测定Apelin-12的水平,测定其糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白以及空腹和餐后2 h血糖、C肽的水平,并对以上指标进行相关性分析。结果与对照组相比,2型糖尿病患者血浆Apelin-12水平显著降低(t=2.70,P=0.01); 2型糖尿病合并心脑血管疾病组血浆Apelin-12的水平与单纯糖尿病组差异无统计学意义(t=-0.44,P=0.67)。多元逐步回归分析显示,在2型糖尿病患者中,空腹血糖与Apelin-12相关(B=-0.12,β=-0.42,t=-2.03,P=0.04)。结论 2型糖尿病患者血浆Apelin-12水平显著降低且与空腹血糖呈负相关。
Aim To investigate the plasma apelin-12 level in the subjects with type 2 diabetes mellitus(T2DM)and its relationship with blood glucose.Methods 41 T2DM patients who were hospitalized in the department of endocrinology of civil aviation general hospital were selected from January 2012 to June 2015,and 44 healthy subjects were enrolled as control group.The patients with T2DM were divided into two groups including one group(21 persons) complicated with hypertension,cardiovascular and cerebrovascular disease and another group(20 persons) without complications for subgroup analysis.The level of apelin-12 was measured by enzyme linked immunosorbent assay.Glycosylated hemoglobin(Hb A1c),cholesterol,triglyceride,low density lipoprotein,fasting blood glucose,2-hour postprandial glucose(2hPG) and C peptide were determined in T2DM group and control group.The correlation between apelin-12 and clinical indicators was analyzed.Results(1) The content of apelin-12 was significantly lower in the T2DM group than in control group(t=2.70,P=0.01).(2) Subgroup analysis showed that there was no significant difference in plasma apelin-12 level between T2DM with cardiovascular and cerebrovascular diseases and T2DM without complications(t=-0.44,P=0.67).(3) With stepwise multiple regression analysis,taking apelin-12 as dependent variable,and age,body mass index,blood pressure,total cholesterol,triglyceride,low density lipoprotein,high density lipoprotein,HbA1c,fasting blood glucose,2-hour postprandial blood glucose,fasting C-peptide and 2-hour postprandial C-peptide were independent variables,fasting blood glucose was associated with apelin-12 in T2DM patients(B=-0.12,β=-0.42,t=-2.03,P=0.04).Conclusion Plasma apelin-12 levels were significantly lower in patients with T2DM and were negatively correlated with fasting blood glucose.
作者
刘凤
易华
彭定琼
段俊婷
刘丽
LIU Feng;YI Hua;PENG Dingqiong;DUAN Junting;LIU Li(Department of Endocrinology,Civil Aviation General Hospital,Beijing 100123,China;Department of Logistics Support,Beijing Branch of China Southern Airlines Limited Company,Beijing 101318,China)
出处
《中国动脉硬化杂志》
CAS
2019年第3期247-250,共4页
Chinese Journal of Arteriosclerosis
