摘要
目的 探讨高血压合并糖尿病患者血压变异性与心率变异性的相关性。方法 选择90例原发性高血压患者为高血压组,92例高血压合并糖尿病患者为高血压合并糖尿病组,90例同期健康体检者为对照组。测定糖化血红蛋白(HbA1c)、血肌酐(Cr)、空腹血糖(FBG)等生物化学指标。进行24 h动态心电图和动态血压同步测量,计算机自动计算各指标。比较三组一般情况、心率变异性、血压变异性的差异,并采用Pearson分析各指标之间的相关性。结果 三组HbA1c、FBG差异有统计学意义,性别、年龄、血脂、血肌酐差异无统计学意义。高血压组、高血压合并糖尿病组心率变异性指标低于对照组(P<0.05),高血压合并糖尿病组心率变异性指标低于高血压组(P<0.05)。三组SBP、DBP、SSD、dSSD、nSSD、sCV、dCV比较差异有统计学意义(P<0.05),其在高血压组、高血压合并糖尿病组高于对照组(P<0.05),在高血压合并糖尿病组高于高血压组(P<0.05),三组DSD、dDSD、nDSD差异无统计学意义(P>0.05)。高血压组、高血压合并糖尿病组24 h平均收缩压标准差SSD与SDNN、SDANN、rMSSD、SDNNIndex、PNN50呈负相关。结论 与高血压患者相比,高血压合并糖尿病患者自主神经功能受损更加明显,随访患者的血压变异性和心率变异性有助于评估病情、改善预后。
Aim To investigate the correlation between blood pressure variability and heart rate variability in patients with hypertension and diabetes. Methods 90 cases of essential hypertension were selected as hypertension group,92 cases of hypertension combined with diabetes mellitus were selected as hypertension combined with diabetes group,90 cases of healthy people were selected as control group at the same time. Glycated hemoglobin( HbA1c),serum creatinine( Cr) and fasting plasma glucose( FBG) were determined. 24 h dynamic electrocardiogram( ECG) and ambulatory blood pressure( BP) were synchronously measured,and each index was calculated automatically by computer. The differences of general condition,heart rate variability and blood pressure variability in the three groups were compared,and the correlation between the indexes was analyzed by Pearson. Results The differences of HbA1c and FBG in the three groups were statistically significant,there was no significant difference in gender,age,blood lipid and Cr. The indexes of heart rate variability of hypertension group and hypertension combined with diabetes group were lower than those of the control group( P<0.05),and the indexes of heart rate variability of hypertension combined with diabetes group were lower than those of the hypertension group( P<0.05). The differences of SBP,DBP,SSD,dSSD,nSSD,sCV and dCV in the three groups were statistically significant( P<0.05),which were higher in the hypertension group and the hypertension combined with diabetes group than those in the control group( P< 0.05),and which were higher in the hypertension combined with diabetes group than those in the hypertension group( P<0.05),and the differences of DSD,dDSD and nDSD had no significance in the three groups( P > 0. 05). There was a negative correlation between 24 h mean systolic blood pressure standard deviationSSD andSDNN,SDANN,r MSSD,SDNNIndex and PNN50 in hypertension group and hypertension combined with diabetes group. Conclusions Compared with hypertensive patients,the impai
出处
《中国动脉硬化杂志》
CAS
2018年第6期617-620,共4页
Chinese Journal of Arteriosclerosis
关键词
原发性高血压
糖尿病
心率变异性
血压变异性
Essential hypertension
Diabetes mellitus
Heart rate variability
Blood pressure variability
