摘要
目的探讨中老年人群远期、中期、近期高敏C反应蛋白(hs-CRP)水平与外周动脉硬化的关系。方法采用前瞻性队列研究方法,在参加2006~2007年度开滦集团职工健康体检的101510例职工中随机分层抽取5852例作为研究对象,符合队列入选标准者5440例。分别于2006~2007年度、2008~2009年度、2010~2011年度对该人群进行健康体检,2010~2011年度进行臂踝脉搏波传导速度(ba PWV)测量。排除基线hs-CRP水平缺失者、基线ba PWV资料缺失及极值者(大于99%分位数值),最终纳入统计分析的有效数据为3948例。依据3次健康体检资料进行基线资料描述,采用多元线性回归分析hs-CRP水平与ba PWV之间的关系,为提高hs-CRP的稳定性,进一步采用3次健康体检hs-CRP水平均值进行统计分析。结果多元线性回归结果显示,hs-CRP水平均与ba PWV水平呈正相关;平均hs-CRP水平与ba PWV水平相关性最大,且随着时间的推进,hs-CRP与ba PWV的相关性逐渐增大。远期、中期、近期及平均hs-CRP水平与ba PWV水平之间的Beta值分别为0.16、0.17、0.21、0.22,经多因素校正后Beta值分别为0.02、0.04、0.05、0.06。结论近期hs-CRP水平与ba PWV水平相关性大于远期hs-CRP,且不同时间多次测量hs-CRP水平的均值与ba PWV水平相关性更强。
Aim To explore the association between long,middle,recent-term high-sensitivity C-reactive protein( hs-CRP) and peripheral arterial sclerosis in middle-aged and old population. Methods Prospective cohort study method was used in our study. A total of 101510 persons who had took part in the 2006 to 2007 kailuan healthy examination were stratified randomly,and 5440 persons with sufficient information for questionnaire and blood biochemical test were recruited. The healthy examinations were taken during 2006-2007,2008-2009 and 2010-2011,respectively. Brachialankle pulse wave velocity( ba PWV) was measured during 2010-2011. The participants who were missed the data of hsCRP or ba PWV and who had ba PWV extreme value data during the healthy examination,were excluded. 3948 participants were included for final analysis. The characteristic of the observation population was described according to the data of the three times healthy examination. Multivariate linear regression was used to analyze the relationship between hs-CRP and ba PWV. Further more,in order to increase the stability of hs-CRP,the mean value of the three times of hs-CRP was used to analysis. Results Multivariate linear regression analysis showed that hs-CRP was positively correlated with ba PWV. Among the long,middle,recent-term hs-CRP and mean hs-CRP,the association between mean hs-CRP and ba PWV was the strongest,and the long-term hs-CRP was the weakest. The correlation between hs-CRP and ba PWV gradually increased with time. The standard regression coefficients( Beta values) were 0. 16,0. 17,0. 21 and 0. 22 respectively between long,middle,recent-term hs-CRP,mean hs-CRP and ba PWV. After adjusted for the other covariates,the standard regression coefficients were 0. 02,0. 04,0. 05 and 0. 06,respectively. Conclusion The correlation between hs-CRP and ba PWV is positive,and the correlation between recent-term hs-CRP and ba PWV is better than long-term hsCRP,but the strongest correlation is the mean hs-CRP that is repeatedly tested in three different time
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第12期1281-1285,共5页
Chinese Journal of Arteriosclerosis
关键词
高敏C反应蛋白
臂踝脉搏波传导速度
动脉硬化
High-sensitivity C-reactive Protein
Brachial-ankle Pulse Wave Velocity
Arterial Sclerosis
