摘要
①目的 探讨口腔鳞状细胞癌肿瘤微血管密度 (MVD)与临床病理因素的关系。②方法 对 5 6例口腔鳞状细胞癌的组织切片采用抗Ⅷ因子单抗进行免疫组织化学染色 ,计算肿瘤MVD。③结果 TNM临床分期Ⅲ、Ⅳ期病人的MVD明显高于Ⅰ、Ⅱ期病人 ( χ2 =4.14,P <0 .0 5 ) ;肿瘤细胞分化程度高的病人MVD明显低于中、低分化病人 ( χ2 =4.2 8,P <0 .0 5 ;P =0 .0 0 1) ;有淋巴结转移病人的MVD明显高于无淋巴结转移病人 ( χ2 =9.75 ,P <0 .0 1)。MVD计数高病人 5年生存率较计数低者差 ( χ2 =5 .72 ,P <0 .0 5 )。
Objective To evaluate the relation between microvessel density(MVD) and clinical pathological features in oral squamous cell carcinoma. Methods An immunohistochemical staining(SABC) was used to quantify MVD in specimens taken from 56 patients with oral squamous cell carcinoma. Results Based on TNM staging, MVD in patients with stages Ⅲ and Ⅳ was higher than that of patient with stages Ⅰ and Ⅱ(χ 2=4.14,P<0.05), MVD was markedly lower in cases with higher tumor-cell differentiation than those with low or moderate differentiation (χ 2=4.28,P<0.05;P=0.001), it was also higher in patients with lymph node metastasis than who were without (χ 2=9.75,P<0.01). The 5-year survival rate was lower in patients with higher MVD (χ 2=5.72, P<0.05). Conclusion Determination of MVD can be used as an index reflecting biological behavior and predicting the prognosis of oral squamous cell carcinoma.
出处
《齐鲁医学杂志》
2003年第1期33-35,共3页
Medical Journal of Qilu
关键词
口腔鳞状细胞癌
预后
微血管密度
carcinoma, squamous cell
mouth
microvessel density
prognosis
