摘要
报道了新的医药中间体2 氯 4,5 二氟苯甲酸合成研究结果。以邻二氟苯为原料,经氯化、酰化、氧化三步反应及粗品精制工艺合成2 氯 4,5 二氟苯甲酸。氯化收率83%,酰化收率86%,酰化产品氧化和粗品精制收率60%。合成总收率为42.8%,产品纯度达到98%以上。
The results of study on the synthesis of 2chloro4,5difluorobenzoic acids that is a new medical intermediate is reported. This product is prepared by the chlorization, acylation, oxidation of orthodifluorobenzene as the material and the purification of raw product. The yield for chlorization and acylation is 83% and 86%, respectively. The yield for acylation product by oxidation and purification is 60%, and the overall yield is 42.8%. The product purity is over 98%.
出处
《应用化工》
CAS
CSCD
2003年第1期39-41,共3页
Applied Chemical Industry
