摘要
改进了除草剂氟噻草胺的合成方法。以肼基二硫代甲酸甲酯、三氟乙酸为原料合成2-甲砜基-5-三氟甲基-1,3,4-噻二唑(4),反应收率81.5%;以对氟硝基苯、丙酮经过催化加氢、酰化、醇解合成N-(4-氟苯基)-N-异丙基-2-羟甲基乙酰胺(8)。化合物(4)与(8)反应合成氟噻草胺,得率94.2%。改进后的工艺反应条件温和,三废少,产品纯度和收率高。
Herbicide flufenacet was synthesized by reaction of 2-（methylsulfonyl）-5-（trifluoromethyl）-l,3,4-thiadiazole with N-（4-fluorophenyl）-2-hydroxy-N-isopropylacetamide with the yield of 94.2%. 2-（Methylsulfonyl）-5- （trifluoromethyl）-l,3,4-thiadiazole was prepared by reaction of methyl hydrazinecarbodithioate with trifluoroacetic acid with the yield of 81.5%. N-（4-Fluorophenyl）-2-hydroxy-N-isopropylacetamide was synthesized by using l-fluoro-4-nitrobenzene as a starting material in four-step procedure.
出处
《农药》
CAS
北大核心
2007年第11期734-736,共3页
Agrochemicals
关键词
氟噻草胺
合成
除草剂
flufenacet
synthesis
herbicide
