摘要
目的探讨甲状腺疾病患者血清超氧化物歧化酶(SOD)、维生素E(VitE)与甲状腺激素的相关性。方法疾病组选自佛山市禅城区中心医院2018年1-2月甲状腺疾病患者136例,对照组选自门诊健康体检者100例,分别抽取静脉血5mL检测各项实验室指标。采用电化学发光法检测甲状腺激素,采用邻苯三酚自氧化法检测SOD活力,采用酶联免疫吸附试验检测VitE水平。结果疾病组血清SOD水平为143.50(134.00,156.75)U/mL,低于对照组的162.00(154.00,168.00)U/mL,差异有统计学意义(P<0.05)。疾病组血清VitE水平[(339±129)mmol/L]明显高于对照组[(245±84)mmol/L],差异有统计学意义(P<0.05);疾病组SOD与FT3(r=0.199,P=0.020)、FT4(r=0.169,P=0.049)呈正相关;与TSH(r=-0.291,P=0.001)呈负相关。疾病组VitE与FT3(r=-0.392,P<0.01)、FT4(r=-0.384,P<0.01)呈负相关;与TSH(r=0.384,P<0.01)呈正相关。结论甲状腺疾病患者血清SOD、VitE水平与甲状腺激素具有相关性,检测甲状腺疾病患者血清SOD、VitE可为临床治疗甲状腺疾病提供新线索。
Objective To investigate the correlation between serum superoxide dismutase(SOD),vitamin E(VitE)and thyroid hormone in patients with thyroid disease.Methods The disease group was selected from 136of thyroid disease patients from January to February in 2018in the central hospital of Chancheng District,Foshan City,and the control group was selected from 100outpatients at the same time.Venous blood was extracted from all the subjects.Thyroid hormones were detected by electrochemiluminescence.SOD activity was measured by pyrogallol auto-oxidation.VitE concentration was detected by ELISA.Results The median serum SOD concentration in the disease group was 143.50(134.00,156.75)U/mL,which was lower than that in the control group[162.00(154.00,168.00)U/mL],difference was statistically significant3 s(P<0.05).The serum VitE concentration in the disease group[(339±129)mmol/L]was significantly higher than that in the control group[(245±84)mmol/L],and the difference was statistically significant(P<0.05).There was a positive correlation between SOD and FT3(r=0.199,P=0.020)and FT4(r=0.169,P=0.049)in the disease group and a negative correlation with thyrotrophin(TSH)(r=-0.291,P=0.001).VitE was negatively correlated with FT3(r=-0.392,P<0.01),FT4(r=-0.384,P<0.01)and positively correlated with TSH(r=0.384,P<0.01).Conclusion Serum SOD,VitE and thyroid hormone are related in patients with thyroid disease.Detection of serum SOD and VitE concentrations in patients with thyroid disease can provide new clues for the treatment of thyroid disease.Abstract:Objective To investigate the correlation between serum superoxide dismutase(SOD),vitamin E(VitE)and thyroid hormone in patients with thyroid disease.Methods The disease group was selected from 136of thyroid disease patients from January to February in 2018in the central hospital of Chancheng District,Foshan City,and the control group was selected from 100outpatients at the same time.Venous blood was extracted from all the subjects.Thyroid hormones were detected by electrochemiluminescenc
作者
刘伟玲
刘伟旗
周少雄
LIU Weiling;LIU Weiqi;ZHOU Shaoxiong(Department of Clinical Laboratory,Chancheng Central Hospital,Foshan,Guangdong528031,China)
出处
《检验医学与临床》
CAS
2019年第6期749-751,754,共4页
Laboratory Medicine and Clinic
基金
广东省佛山市卫生和计划生育局医学科研课题(20180176)
