摘要
临床药效是兽药制剂最关键的一项研究指标。本试验采用人工诱发鸡球虫病的治疗试验来进行超微粉中兽药'鸡球虫散'的临床药效研究,试验攻虫为鸡柔嫩艾美耳球虫南昌株。试验共选取同1日龄、大小均匀伊莎小公鸡240羽,分成8组,每组3个样本,每个样本10个重复,以抗球虫指数(ACI)作为疗效判定依据。结果:阴性对照组(不攻虫,不用药)、阳性对照组(攻虫,不用药)、细粉鸡球虫散组(1%细粉鸡球虫散拌料,约300目)、地克珠利组(5μg/g地克珠利拌料)、低剂量超微粉鸡球虫散组(0.5%超微粉鸡球虫散拌料,约1 000目,下同)、高剂量超微粉鸡球虫散组(1%超微粉鸡球虫散拌料)、低剂量超微粉鸡球虫散-地克珠利联用组(0.5%超微粉鸡球虫散+2.5μg/g地克珠利拌料)和高剂量超微粉鸡球虫散-地克珠利联用组(1%超微粉鸡球虫散+2.5μg/g地克珠利拌料)的ACI依次为200.00、88.73、146.45、178.28、143.99、160.82、170.31和188.04,6个用药组中,高剂量超微粉鸡球虫散-地克珠利联用组为显效(ACI≥180),地克珠利组、高剂量超微粉鸡球虫散组和低剂量超微粉鸡球虫散-地克珠利联用组为有效(ACI=160~179),细粉鸡球虫散组与低剂量超微粉鸡球虫散组为低效(ACI<160)。说明中兽药超微粉碎后不仅能提高其药效,而且超微粉中兽药制剂与化学兽药联用不仅能增强药效,而且降低了化学兽药的用量。
The clinical efficacy of ultrafine traditional chinese veterinary medicine Chicken Coccidia Powder(CCP)was studied in this trial.The trial chickens were artificially infected coccidiosis by Nanchang strain of chicken E.tenella and then treated according to the design.The 240 test Isa cockerel of the same age,same weight were selected and divided into eight groups,three samples each group,10 repeated per sample,and the Anticoccidial Index(ACI)was used as a index for therapeutic efficacy.The ACI of the negative control group(no insect attack,without medication),the positive control group(insect attack,without medication),fine CCP group(1%fine CCP feeding,about 300 mesh),the Diclazuril group(5μg/g Diclazuril feeding),low-dose ultrafine CCP group(0.5%ultrafine CCP feeding,about 1 000 mesh,the same below),high-dose ultrafine CCP group(1%ultrafine CCP feeding),lowdose combination of ultrafine CCP and Diclazuril group(0.5%ultrafine CCP+2.5μg/g Diclazuril feeding)and high-dose combination of ultrafine CCP and Diclazuril groups(1%ultrafine CCP+2.5μg/g Diclazuril feeding)were 200.00,88.73,146.45,178.28,143.99,160.82,170.31 and 188.04,respectively.In six treatment groups,the high-dose combination of ultrafine CCP and Diclazuril groups was the efficient(ACI≥180).The Diclazuril group,high-dose ultrafine CCP group and low-dose combination of ultrafine CCP and Diclazuril group were in effect(ACI=160~179),fine CCP group and low-dose ultrafine CCP group was low efficient(ACI<160).The results showed that ultrafine traditional chinese veterinary medicine can improve efficacy after ultrafine grinding,and they combined with chemical veterinary medicine not only could enhance the efficacy,but also reduced the amount of chemical veterinary medicine.
作者
李龙瑞
张吉鹍
张庆生
赖贻奎
黎观红
陈金兴
邵智军
李检香
LI Longrui;ZHANG Jikun;ZHANG Qingsheng;LAI Yikui;LI Guanhong;CHEN Jinxing;SHAO Zhijun;LI Jianxiang(Veterinary Medicine Research Institute,Jiangxi New World Pharmaceutical Co,Ltd.,Xiajiang 331400:Institute of Animal Science,Jiangxi Academy of Agricultural Sciences,Nanchang 330200;Jian Animal Husbandry and Vet?erinary Bureau,Jian 343000;College of Animal Science and Technology,Jiangxi Agricultural University,Nan?chang 330045,China)
出处
《东北农业科学》
北大核心
2019年第4期50-58,共9页
Journal of Northeast Agricultural Sciences
基金
江西省重点研发计划项目(20132BBF60043)
国家自然科学基金项目(31360563)
关键词
抗球虫指数
地克珠利
超微粉鸡球虫散
细粉鸡球虫散
临床药效
Anticoccidial Index(ACI)
Diclazuril
Ultrafine Chicken Coccidia Powder(CCP)
Fine CCP
Clinical efficacy
