摘要
测定 2型糖尿病肾病 (DN)患者和正常对照者血清基质金属蛋白酶 9(MMP 9) ,MMP组织抑制物 1 (TIMP 1 ) ,Ⅳ型胶原水平 ,以尿白蛋白排泄率判断DN严重程度。结果显示血清TIMP 1和Ⅳ型胶原水平随DN严重程度而明显升高 ,MMP 9呈降低趋势。TIMP 1、MMP
Serum metalloproteinase matrix (M MP )-9, tissue inhibitor of metalloproteinase (TIMP)-1 and type Ⅳ collagen level s were measured in patients with diabetic nephropathy (DN). The severity of DN w as determined by urinary albumin excretion rate. The results show that signific ant increases of serum TIMP-1 and type Ⅳ collagen depend on severity of DN, wh ile MMP-9 tends to decline. TIMP-1 and MMP-9 seem to participate in the patha genesis of DN.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2003年第1期52-53,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
基质金属蛋白酶
基质金属蛋白酶组织抑制物1
糖尿病肾病
Matrix metalloproteinases
Tissue inhib itor of metalloproteinase-1
Diabetic nephropathies (Chin J Endocrinol Metab, 2003,19:52-53)
