摘要
目的 采用固体分散技术 ,提高葛根素的体外溶出速率。方法 分别以聚乙二醇 60 0 0 ,泊洛沙姆 ,聚乙二醇 60 0 0 聚氧乙烯 (40 )硬脂酸酯 (又名S 40 )的熔合物 (1∶3)为载体 ,熔融法制备葛根素的固体分散体。采用DSC法鉴别药物在固体分散体中的存在状态 ,并进行体外溶出度实验。结果 各种固体分散体均能加快药物的溶出速率 ,载体比例愈大 ,药物溶出越快。葛根素在PEG60 0 0的固体分散体中以微细结晶存在。结论 葛根素 PEG60 0
OBJECTIVE: The solid dispersion method was used to increase the dissolution of puerarin in vitro. METHODS: Puerarin solid dispersion was prepared respectively with melting method using PEG6000, poloxamer and PEG6000-S-40 melting mixture as carriers. DSC was used to determine the status of puerarin in solid dispersions. The dissolution characteristics in vitro were studied in artificial gastric juice. RESULTS: The dissolution rates in vitro of all puerarin solid dispersions were larger than the pure drug and showed that higher carrier-puerarin ratio led to faster drug dissolution. In puerarin-PEG6000 solid dispersion, puerarin existed as fine crystalline. CONCLUSION: Puerarin-PEG6000 solid dispersion was potent in improving the dissolution of puerarin and had the potential for practical use.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2003年第1期42-44,共3页
Chinese Pharmaceutical Journal
