摘要
为探讨载脂蛋白E基因多态性对血脂及高血压病的影响 ,采用聚合酶链式反应—限制性片段多态性方法测定 112例原发性高血压病人及 118例非高血压病对照的载脂蛋白E基因型。结果发现高血压病患者中ε4等位基因频率及载脂蛋白Eε4携带者显著高于对照组 (P <0 .0 5 )。载脂蛋白Eε4携带者的总胆固醇和低密度脂蛋白胆固醇水平显著高于载脂蛋白Eε2携带者 (P <0 .0 5 ) ,载脂蛋白Eε3 ε3携带者的低密度脂蛋白胆固醇水平也显著高于载脂蛋白Eε2携带者 (P <0 .0 5 )。载脂蛋白Eε4携带是高血压病的独立危险因素 (P <0 .0 5 )。研究表明载脂蛋白E基因多态性影响个体的血脂和脂蛋白水平 。
Aim To explore the effect of apolipoprotein E (Apo E) polymorphism on lipid and essential hypertension. Methods Polymerase chain reaction restricted fragments length polymorphism was used to determine the Apo E genotypes in 112 cases with essential hypertension and 118 controls without hypertension. Results The ε4 allele frequency and the Apo E ε4 carriers was significantly higher in the hypertensive patient group than that in the group of normotensive control (P<0.05). The subjects carrying Apo E ε4 had significantly higher levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) than those carrying Apo E ε2 (P<0.05);the Apo E ε3/ε3 carriers had significantly higher LDLC levels than the Apo E ε2 carriers (P<0.05). The Apo E ε4 was an independent risk factor for essential hypertension (P<0.05). Conclusions The Apo E gene polymorphism affects plasma levels of lipids and lipoproteins. The Apo E ε4 may be an important risk factor for essential hypertension.
出处
《中国动脉硬化杂志》
CAS
CSCD
2002年第6期517-520,共4页
Chinese Journal of Arteriosclerosis
关键词
载脂蛋白E
基因多态性
血脂
高血压
Apolipoprotein E
Genes
Polymorphism
Lipids
Hypertension
