摘要
目的 :观察培高利特治疗超老年帕金森病 (PD)的疗效与副作用。方法 :采用回顾性分析 ,10例超老年PD患者在维持原治疗的基础上加用培高利特 2 5～ 5 0 μg·d 1 ,分 2或 3次 ,po ,疗程 1.5～ 60个月。结果 :8例用该药有效 ,有效率 80 .0 % ,维持量 2 5 0～ 75 0 μg·d 1 ,4例有轻微不良反应 ,便秘常见。结论 :用培高利特治疗超老年PD ,耐受性较好 ,可与苯海索、金刚烷胺、左旋多巴合用 。
Objective:To survey the therapeutic effectiveness and safety rate of pergolide mesylate in the treatment of very old patients with Parkinson's disease(PD). Methods:A retrospective analysis was made for 10 very old patients with PD treated with pergolide mesylate on the basis of routine treatment. The daily dosage of pergolide mesylate was 25～250 μg given p.o. in 2 or 3 diveded doses. The course of treatment lasted 1.5～60 months. Results:The effective rate was 80.0% (8/10). The maintenance dose was 250～750 μg·d -1. 4 of the 10 patients had slight adverse reactions, including commonly nausea and constipation. Conclusion:Pergolide was shown to have a fairly good therapentic effect in the treatment of very old patients with PD. Pergolide may be used in combination with artane, Amantadine and levodopa for augmenting the therapeutic effect.
出处
《医药导报》
CAS
2003年第2期86-87,共2页
Herald of Medicine
关键词
培高利特
治疗
超老年
帕金森病
Pergolide
Parkinson's disease/very old patients
