摘要
目的探讨中药消郁汤与西药舍曲林治疗抑郁症的疗效与副作用。方法将260例和180例抑郁症患者分别用中药消郁汤(治疗组)及西药舍曲林(对照组)治疗,共治疗6周。用汉密尔顿抑郁量表(HAMD)评估疗效,不良反应和安全性用副反应量表(TESS)和实验室检查评定。结果两组在治疗后第1、2、4、6周末HAMD评分与疗前相比均明显下降,均有显著性差异(P<0.01)。治疗组成本较对照组低,患者更易接受。治疗期间治疗组副反应明显低于对照组,差异非常显著(P<0.01)。结论消郁汤和舍曲林治疗抑郁症疗效好,消郁汤较舍曲林的副反应少且症状轻微,依从性好,安全性高。
Objectiv depression. Methods e To evaluate the efficacy and side effects of XiaoYu decoction and sertraline in the treatment of A total of 440 patients were randomized into study group （260 cases） and control group （180 cases）, which were treated with XiaoYu decoction and sertraline respectively for 6 weeks. Hamilton Depression Rating Scale （HAMD） was used to assess the efficacy. Treatment Emergent Symptom Scale （TESS） and results of laboratory examination were used to assess the side effects. Results The total scores of HAMD in both groups were significantly lower at the 1st, 2nd, 4th and 6th weekend after treatment than the baseline （P 〈0.01 ）. The cost in study group was relatively low, and side effects in study group was significantly slighter than that in control group （ P 〈 0.01 ）. Conclusion Both XiaoYu decoction and sertraline have satisfactory efficacy in the treatment of depression. Compared with sertraline, XiaoYu decoction is more tolerable because of its higher safety and fewer side effects.
出处
《精神医学杂志》
2011年第2期112-114,共3页
Journal of Psychiatry
关键词
抑郁症
消郁汤
舍曲林
Depression XiaoYu decoction Sertraline
