摘要
目的 评价新辅助化疗治疗骨肉瘤的临床疗效。方法 新辅助化疗保肢术治疗骨肉瘤 38例。术前超大剂量化疗 2个疗程 ,第 12周手术 ,术后化疗 3～ 5个疗程 ,根据肿瘤坏死率测定调整术后化疗方案。手术方法 :关节置换 17例 ,同种异体骨移植 9例 ,自体骨移植 7例 ,肿瘤骨灭活再植 2例 ,肿瘤切除 3例。结果 肿瘤坏死率测定 :>90 % 32例 ,<90 % 4例 ;未测定 2例。 3年无瘤生存率71 1% ,5年无瘤生存率 6 5 8%。
Objective To evaluate the clinical effect of the new adjuvant chemotherapy for the treatment of osteosarcoma. Methods 38 cases were treated with new adjuvant chemotherapy and limb salvage surgery in the following procedure: preoperative ultra high dose chemotherapy for two periods, surgery in the 12th week, and postoperative chemotherapy for 3～5 courses, postoperative chemotherapy regimen was adjusted according to the tumor necrosis rate.Surgical methods included endoprosthestic replacement in 17 cases,bone allograft in 9 cases,bone autograft in 7 cases, devitalized tumor bone reinplantation was done in 2 cases,tumor resection in 3 cases. Results The tumor necrosis rate was over 90% in 32 cases, under 90% in 4 cases,and the tumor necrosis rat of the other 2 cases was not examined. Relaspse free survival for 3 years and 5 years after surgery was 71 1% and 65 8%, respectively. Conclusion The new adjuvant chemotherapy combined with limb salvage surgery is an ideal therapy for osteosarcoma.
出处
《临床骨科杂志》
2002年第4期282-284,共3页
Journal of Clinical Orthopaedics
