摘要
目的 研究弓形虫感染与小儿疾病的关系。 方法 以 12 4 6例住院儿童为实验组 ,2 6 7名健康儿童为对照组 ,使用统一调查表问卷调查 ,同时采集静脉血 ,分离血清 ,采用双抗体夹心酶标一步法检测血清弓形虫循环抗原。 结果 实验组和对照组弓形虫循环抗原阳性率分别为 3.5 3%和 1.87% ,两组阳性率差异无显著性。早产儿、黄疸、新生儿缺氧缺血性脑病 (HIE)、肺炎、癫痫组弓形虫循环抗原均为阴性。上呼吸道感染、支气管炎、腹泻病组弓形虫循环抗原阳性率与对照组比较差异无显著性 (P>0 .0 5 )。喉炎 (包括喉炎、急性喉 -气管 -支气管炎 )、热性惊厥、哮喘 (包括支气管哮喘、喘息性支气管炎 )组弓形虫循环抗原阳性率与对照组比较差异有显著性 (0 .0 5 >P>0 .0 1或 P≤ 0 .0 1)。 结论 虽然住院儿童与健康儿童血清弓形虫循环抗原阳性率差异无显著性 ,但某些疾病患儿弓形虫循环抗原阳性率与对照组比较 ,差异有显著性 ,提示弓形虫急性感染可能是这些疾病的一种病因。
Objective To study the relationship between toxoplasmosis and diseases of children. Methods 1 246 inpatients of children was as the experimental group and 267 normal children was as the control group. The unify investigation form were filled in two groups. The vein blood were drawn and the sera were divided. The circulating antigen(CAg) of T. gondii in sera were examined with the twin antibodys Sandwich ELISA. Results The positive rates of CAg of T. gondii in experimental group and control group were 3.5% and 1.87% respectively. There were no significant difference in two units. No CAg was detected out in preterm infant, jaundice, hypoxic ischemic encephalopathy(HIE), epilepsy units. There were no significant differences in acute upper respiratory infection, acute bronchitis, diarrhea and normal control units ( P >0.05). There were significant differences in acute laryngitis, febrile convulsion, bronchial asthma and control group(0.05> P >0.01 or P ≤0.01). Conclusion Though there was no significant difference in positive rates of CAg for T. gondii in inpatients of children and normal control children, but there were significant differences in some diseases and normal control units. Acute toxoplasmosis may be a cause of some diseases mentioned above.
出处
《中国寄生虫病防治杂志》
CSCD
2002年第6期352-354,共3页
Chinese Journal of Parasitic Disease Control
基金
深圳市医药卫生科技项目 (No.1 9990 60 2 9)
深圳市盐田区科技局科研基金项目 (No.2 0 0 1 - KJJF- 0 1 9)
关键词
弓形虫感染
循环抗原
检测
住院儿童
Infection of Toxoplasma gondii
circulating antigen
test
inpatient
