摘要
目的:评估肠炎Ⅰ号灌肠方治疗溃疡性结肠炎的疗效及对粪中性粒细胞衍生蛋白的影响。方法:将64例轻、中度溃疡性结肠炎患者随机分为两组各32例。治疗组患者予肠炎Ⅰ号灌肠方保留灌肠;对照组患者予美沙拉嗪肠溶片口服。治疗结束后,评估临床疗效,并记录患者治疗前后粪便中的中性粒细胞衍生蛋白的含量。结果:治疗组总有效率为90.63%,对照组总有效率为87.50%,两组疗效比较,差异无统计学意义(P>0.05);两组患者治疗后粪中性粒细胞衍生蛋白含量均降低,差异均有统计学意义(P<0.05);两组患者治疗后粪中性粒细胞衍生蛋白含量比较,差异无统计学意义(P>0.05);治疗组患者腹泻、脓血便消失时间低于对照组(P<0.05)。结论:肠炎Ⅰ号灌肠方治疗轻、中度溃疡性结肠炎的疗效显著,能有效减轻肠黏膜的炎症水平。
Objective:To evaluate the clinical efficacy of Changyan Guanchang Fang No.Ⅰin treating ulcerative colitis and its effect on fecal Neutrophil derived protein.Methods:A total of 64 patients with mild and moderate ulcerative colitis were randomly divided into two groups,32 patients in each group.Patients were treated by Changyan Guanchang Fang No.Ⅰin treatment group and mesalazine enteric-coated tablets in control group.At the end of the treatment,the clinical efficacy was evaluated and the content of Neutrophil derived protein was recorded before and after treatment.Results:The effective rate was 90.63%in the treatment group and 87.50%in the control group,and the effective rates among the two groups showed no statistical significance(P>0.05).The number of Neutrophil derived protein decreased in the two groups(P<0.05)and there was no statistically significant difference between the two groups(P<0.05).The treatment group showed lower disappearance time of diarrhea and pus and blood stool than that control group(P<0.05).Conclusion:Changyan Guanchang Fang No.Ⅰshows distinct curative effect on mild and moderate UC,and it can effectively reduce the inflammation of the intestinal mucosa.
作者
纪翔
王建民
侯勇
李明
唐冉
JI Xiang;WANG Jian-min;HOU Yong;LI Ming;TANG Ran(Graduate School,Anhui University of Chinese Medicine,Hefei Anhui 230038,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei Anhui 230031,China)
出处
《中医药导报》
2019年第7期58-60,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
安徽省科技攻关计划项目(1501041151)
安徽高校自然科学研究项目(KJ2016A396)
