摘要
目的观察自拟中药保留灌肠汤剂在溃疡性结肠炎治疗中的应用效果。方法随机选取2019年1月—2020年12月该院60例溃疡性结肠炎患者,随机分组,每组30例,对照组采取美沙拉嗪治疗,观察组采取美沙拉嗪治疗的同时,联合中药保留灌肠方法治疗,对两组治疗效果进行比较。结果治疗总有效率方面,观察组(93.33%)比对照组(73.33%)高,差异有统计学意义(χ^(2)=4.320,P=0.038);血性腹泻、腹痛和里急后重症状积分方面,治疗前,两组对比差异无统计学意义(t=0.269、1.049、0.439,P=0.788、0.298、0.662);治疗后,观察组较对照组低,差异有统计学意义(t=3.567、11.817、18.432,P<0.001);DAI评分方面,两组治疗前差异无统计学意义(t=0.197,P=0.845);治疗后观察组较对照组优,差异有统计学意义(t=8.564,P<0.001)。血小板计数和血沉方面,治疗前,两组比较差异无统计学意义(t=0.031、0.175,P=0.975、0.862);治疗后,与对照组比较,观察组更低,差异有统计学意义(t=2.821、3.228,P=0.007、0.002);不良反应总发生率方面,观察组为3.33%,对照组为26.67%,观察组比对照组低,差异有统计学意义(χ^(2)=4.706,P=0.030)。社会功能、生理功能、躯体疼痛、精神健康、情感职能和生理职能评分方面,与对照组比较,观察组更高,差异有统计学意义(t=11.640、8.798、9.882、12.787、17.435、13.065,P<0.001)。结论溃疡性结肠炎临床治疗中,采取美沙拉嗪联合中药保留灌肠方法不仅可以减轻患者腹痛腹泻等临床症状,还有助于患者及早恢复健康,值得推广。
Objective To observe the application effect of self-made traditional Chinese medicine retention enema decoction in the treatment of ulcerative colitis.Methods 60 patients with ulcerative colitis in the hospital from January 2019 to December 2020 were randomly selected.Randomly divided into groups,30 cases in each group,the control group was treated with mesalazine,and the observation group was treated with mesalamine combined with traditional Chinese medicine retention enema.The treatment effects of the two groups were compared.Results In terms of the total effective rate of treatment,the observation group(93.33%)was higher than the control group(73.33%),and the difference was statistically significant(χ^(2)=4.320,P=0.038).In terms of bloody diarrhea,abdominal pain and tenesmus,before treatment,there was no statistically significant difference between the two groups(t=0.269,1.049,0.439,P=0.788,0.298,0.662).After treatment,the observation group was lower than the control group,and the difference was statistically significant(t=3.567,11.817,18.432,P<0.001).In terms of DAI score,there was no statistically significant difference between the two groups before treatment(t=0.197,P=0.845).After treatment,the observation group was better than the control group,the difference was statistically significant(t=8.564,P<0.001).In terms of platelet count and erythrocyte sedimentation rate,before treatment,there was no statistically significant difference between the two groups(t=0.031,0.175,P=0.975,0.862).After treatment,with the control group,the observation group was lower,and the difference was statistically significant compared(t=2.821,3.228,P=0.007,0.002).In terms of the total incidence of adverse reactions,the observation group was 3.33%,the control group was 26.67%,the observation group was lower than the control group,and the difference was statistically significant(χ^(2)=4.706,P=0.030).Compared with the control group,the scores of social function,physiological function,physical pain,mental health,emotional function an
作者
谷圣青
邵亮
王子美
李远
赵良洁
GU Shengqing;SHAO Liang;WANG Zimei;LI Yuan;ZHAO Liangjie(Department of Gastroenterology,People's Hospital of Shouguang City,Shouguang,Shandong Province,262700 China;Department of Traditional Chinese Medicine,Shouguang City Traditional Chinese Medicine Hospital,Shouguang,Shandong Province,262700 China)
出处
《世界复合医学》
2022年第2期150-154,共5页
World Journal of Complex Medicine
基金
潍坊市卫生健康委员会中医药科研项目[2021年(第4类)第029号]。
关键词
中药保留灌肠汤剂
溃疡性结肠炎
美沙拉嗪
Traditional Chinese medicine retention enema decoction
Ulcerative colitis
Mesalazine
