摘要
目的 :探究恩度持续静脉泵注联合TP化疗治疗进展期卵巢癌的临床效果及其对血清KLK5及SMRP水平的影响。方法 :将我院2012年1月～2016年1月期间收治的106例卵巢癌患者为研究对象,将患者按随机数字表法为观察组和对照组,每组各53例。对照组患者采用TP化疗进行治疗,观察组患者在对照组基础上联合恩度持续静脉泵注治疗。比较两组治疗效果以及血清KLK5、SMRP等变化。结果 :观察组临床疗效明显高于对照组(81.1%vs 66.0%);两组不良反应发生相比,差异无统计学意义;观察组血清CA125、CA153、HE4、CEA、βHCG等肿瘤因子明显低于对照组,差异具有统计学意义;观察组血清清KLK5、SMRP、VEGF、Ang-2等明显低于对照组,差异具有统计学意义。结论 :恩度持续静脉泵注联合TP化疗能够降低卵巢癌患者血清KLK5、SMRP表达,抑制肿瘤血管因子生成因子表达,从而抑制肿瘤组织增殖,提高治疗效果。
Objective To investigate the clinical effect of Endurian continuous intravenous infusion combined with TP chemotherapy in the treatment of advanced ovarian cancer and its effect on serum KLK5 and SMRP levels.Methods A total of106 patients with ovarian cancer who were treated in our hospital from January 2012 to January 2016 were enrolled in this study.The patients were randomly divided into observation group(n=53)and control group(n=53).The patients in the control group were treated with TP chemotherapy.The patients in the observation group were treated with continuous intravenous infusion of Endu on the basis of the control group.The therapeutic effects of two groups and the changes of serum KLK5 and SMRP were compared.Results The clinical efficacy of the observation group was significantly higher than that of the control group(81.1%vs 66.0%).There was no significant difference between the two groups in the incidence of adverse reactions.The tumor factors such as CA125,CA153,HE4,CEA andβHCG in the observation group were significantly lower than those in the control group.The levels of serum KLK5,SMRP,VEGF and Ang-2 in the observation group were significantly lower than those in the control group,with statistical significance.Conclusion Endood continuous intravenous infusion of TP combined with chemotherapy can reduce the expression of serum KLK5 and SMRP in ovarian cancer patients and inhibit the expression of tumor angiogenetic factors,thereby inhibiting the proliferation of tumor tissue and improving the therapeutic effect.
作者
郑进
杨红军
谭君花
Zheng Jin;Yang Hong-jun;Tan Jun-hua(Department of Obstetrics and Gynecology,Sichuan Second Hospital of Traditional Chinese Medicine,Chengdu 610031,China)
出处
《湖南师范大学学报（医学版）》
2019年第2期108-111,共4页
Journal of Hunan Normal University(Medical Sciences)
