摘要
目的:研究小剂量糖皮质激素联合甲氨蝶呤在类风湿关节炎达标治疗中应用价值及对患者血清TNF-a水平的影响。方法:选取2012年10月~2016年10月期间在我院接受诊治的80例类风湿关节炎患者作为研究对象,根据随机数表法分为对照组、研究组,各40例。对照组患者采用来氟米特联合甲氨蝶呤治疗,研究组患者在对照组治疗基础上加用强的松,持续治疗6个月。比较两组患者治疗效果及血清炎性因子水平变化。结果:治疗6个月后两组患者晨僵时间、关节肿胀数均低于治疗前,且研究组低于对照组,差异有统计学意义;治疗6个月后两组患者疼痛VAS评分均低于治疗前,且研究组低于对照组,差异有统计学意义;治疗6个月后两组患者的血清IL-6、TNF-a水平均低于治疗前,且研究组低于对照组,差异有统计学意义。结论:小剂量糖皮质激素联合甲氨蝶呤在类风湿关节炎患者达标治疗中应用效果显著,能有效减轻炎症反应,缓解临床症状,控制病情发展。
Objective To study the effect of low-dose glucocorticoid combined with methotrexate in the treatment of rheumatoid arthritis and the effect of serum TNF-a. Methods A total of 80 patients with rheumatoid arthritis who underwent treatment in our hospital from October 2012 to October 2016 were selected as subjects. All the patients were divided into control group and study group according to random number table method, 40 cases in each group. In the control group, patients were treated with leflunomide combined with methotrexate, and the patients in the study group were given prednisone on the basis of the control group, continuous treatment for 6 months. The therapeutic effect and the level of serum inflammatory factors were compared between the two groups. Results After 6 months of treatment, the number of morning stiffness and joint swelling were lower than those before treatment, and the difference was statistically significant. The VAS score of the two groups was lower than that of the control group after 6 months of treatment, and the difference was statistically significant. The levels of serum IL-6 and TNF-a in the two groups were lower than those before treatment, and the difference was statistically significant. Conclusion Small dose of glucocorticoid combined with methotrexate in patients with rheumatoid arthritis in the treatment of significant treatment, can effectively reduce the inflammatory response, relieve clinical symptoms, control the disease progression.
出处
《湖南师范大学学报（医学版）》
2018年第1期28-30,共3页
Journal of Hunan Normal University(Medical Sciences)
基金
北京市优秀人才培养资助项目(2013A008006000001)
