摘要
目的:观察绝经过渡期功血患者刮宫后行曼月乐与米非司酮间断给药对子宫内膜厚度、性激素的影响。方法:将2013年2月~2015年6月来我院治疗绝经过渡期功血的患者104例,按照完全随机的原则将其均分为观察组和对照组;刮宫术后5天,观察组行曼月乐置入治疗,对照组给予米非司酮间断口服治疗;观察两组患者的临床疗效,治疗前后子宫内膜厚度、月经量、血红蛋白浓度及性激素变化情况,不良反应发生率。结果:观察组的临床有效率(88.46%)显著高于对照组(59.62%),差异具体统计学意义。治疗后两组患者的子宫内膜厚度、月经量、血红蛋白浓度、FSH、E2、PRL、LH、P均有改善,但观察组患者各项指标的改善情况均显著优于对照组,差异具有统计学意义。对照组不良反应发生率(11.54%)显著高于观察组(42.31%),差异具有统计学意义。结论:曼月乐和米非司酮间断给药治疗方式治疗围绝经期功血均具有一定的临床疗效,其中曼月乐的临床疗效更加显著,不良反应发生率低,安全性高,值得临床上推广。
Objective To observe the effects of menopause transition period dysfunctional uterine bleeding in patients with uterine curettage was performed after Mirena and mifepristone intermittent administration of endometrial thickness, sex hormone effects. Methods 104 cases of patients with menopausal transition dysfunctional uterine bleeding were collected from our hospital from February 2013 to June 2015, in accordance with the principle of completely random will score into the observation group and the control group; after 5 days, dilatation and curettage, observation group underwent Mirena placement for the treatment, control group was given mifepristone orally intermittent treatment; to observe the clinical efficacy of the two groups of patients, before and after the treatment of endometrial thickness, menstruation, hemoglobin concentration, and sex hormone change situation, adverse reaction incidence. Results The clinical effective rate of the observation group(88.46%) was significantly higher than that of the control group(59.62%), and the difference was statistically significant. After treatment, two groups of patients with endometrial thickness, menstruation, hemoglobin concentration, FSH, E2, PRL, LH, P were improved, but the observation group indicators improved significantly better than the control group, the difference has statistical significance. The adverse reaction rate(11.54%) of control group was significantly higher than that of the observation group(42.31%), and the difference was statistically significant. Conclusion Mirena and mifepristone interrupted to drug therapy in the treatment of peri menopausal dysfunctional uterine bleeding has certain curative effect, the clinical curative effect of Mirena is more significant, low incidence of adverse reactions, high safety, it is worth clinical promotion.
出处
《湖南师范大学学报（医学版）》
2017年第5期155-158,共4页
Journal of Hunan Normal University(Medical Sciences)
