摘要
目的对比分析多西他赛与奥沙利铂分别联合氟尿嘧啶类药物在晚期胃癌一线化疗中的疗效及毒副反应,评价2种不同化疗方案在晚期胃癌化疗中的应用价值。方法 57例晚期胃癌患者分为多西他赛联合氟尿嘧啶类化疗组(A组,26例)和奥沙利铂联合氟尿嘧啶类化疗组(B组,31例),所有患者均化疗至少4周期,按RECIST标准评价并比较2组的客观疗效,按NCI-CTC 3.0标准评价并比较毒副反应发生情况。结果A组有效率为38.4%,疾病控制率为76.9%,中位疾病进展时间5.8个月,中位总生存时间12.5个月;B组分别为38.7%、80.6%、5.3个月、14.0个月,比较差异均无统计学意义(P>0.05)。毒副反应方面,A组白细胞减少总发生率为88.5%,高于B组的61.3%(P<0.05);A组外周神经毒性发生率为30.8%,显著低于B组的67.7%(P<0.05)。结论多西他赛联合氟尿嘧啶类化疗方案与奥沙利铂联合氟尿嘧啶类化疗方案治疗晚期胃癌疗效相当,毒副反应有差异,但均属可耐受范围,2种方案均可作为晚期胃癌化疗方案,临床制定化疗方案需个体化选择。
Objective To compare the efficacy and toxicities of docetaxel or oxaliplatin combined with fluorouracil regimens in the treatment of advanced gastric cancer. Methods Fifty-seven patients with advanced gastric cancer were treated with cytotoxic drugs,were divided into 2 groups,and were given docetaxel( A group,26 patients) or oxaliplatin( B group,31 patients) combined with fluorouracil for at least 4 cycles,the efficacy and toxicities of the two groups were compared with RECIST standard and NCI-CTC 3. 0 standard. Results The A group: the objective remission rate was 38. 4%,the disease control rate was 76. 9%,the median time to progression was 5. 8 months,the median overall survival was 12. 5 months; those in the B group were 38. 7%,80. 6%,5. 3 months and 14. 0 months( P > 0. 05). The toxicities: the total incidence of leukopenia in the A group was 88. 5%,and was 61. 3% in the B group( P < 0. 05); the incidence of peripheral nerve toxicity in the A group( 30. 8%) was higher than that of the B group( 67. 7%)( P < 0. 05). Conclusion The efficacy of docetaxel or oxaliplatin combined with fluorouracil regimens are similar in the treatment of advanced gastric cancer,the toxicities between the two drugs in the chemotherapy were slightly,while showed different characteristics. Both of them can be used for advanced gastric cancer,and the clinical chemotherapy should be individualized choice.
出处
《肿瘤基础与临床》
2016年第3期206-209,共4页
journal of basic and clinical oncology
关键词
晚期胃癌
多西他赛
奥沙利铂
化疗
advanced gastric cancer
docetaxel
oxaliplatin
chemotherapy
