摘要
目的 观察复方虫草精华 (Lungfit)对大鼠离体心脏缺血 /再灌注损伤是否存在保护作用。方法 Lungfit分小、大两个剂量 (1 60、32 5mg/kg.d- 1 )给大鼠连续灌胃给药 1 0天后 ,取心脏 ,用Langendorff装置逆行恒压灌流 ,左心室内置乳胶水囊和换能器相连 ,分别测定缺血前后各组心脏的心功能参数值。结果 缺血前 ,Lungfit灌胃大鼠离体心脏的各项心功能参数值与对照组相比无显著差异 (P >0 0 5) ;缺血 30min后的再灌注期间 ,Lungfit灌饲的大鼠心脏的心率、冠脉流量及心肌舒缩功能的改善明显优于对照组 (P <0 0 5或P <0 0 1 )。结论 Lungfit对心肌缺血
Objective To study the effect of Cordyceps sinensis compound (Lungfit) on myocardial ischemia/reperfusion injury in isolated rat heart.Methods Langendorff perfusion technique of rat heart was used to detect the myocardial function parameter at every 5 min intervals before ischemia and after reperfusion. Lungfit was administered by intragastric gavage at two different doses (160, 325 mg/kg.d -1 ) for 10 days consecutively.Results No statistical difference was observed between the Lungfit group and the control group before ischemia ( P >0 05). However, in the reperfusion period after 30 min global ischemia, the recovery of heart rate, coronary flow and systole/diastole function was markedly superior to that of control group.Conclusion Lungfit could produce a protective effect on myocardial ischemia/reperfusion injury.
出处
《中国血液流变学杂志》
CAS
2002年第4期279-282,共4页
Chinese Journal of Hemorheology
基金
香港保健协会资助项目
