摘要
目的:观察与评估原发性肝癌经肝动脉化疗栓塞(TACE)术前使用静脉持续泵入恩度治疗的临床疗效。方法:选取2015年10月-2016年3月期间本院收治的66例原发性肝癌患者为研究对象,将其根据治疗方式的不同分为对照组(TACE组)33例和观察组(TACE联合恩度组)33例。统计与比较两组患者的临床疗效、毒副反应发生率及治疗前后的肿瘤标志物及复发转移相关指标。结果:观察组的临床总有效率显著高于对照组(P<0.05),治疗后的肿瘤标志物及复发转移相关指标均低于对照组(P<0.05),而两组的毒副反应发生率无显著性差异(P>0.05)。结论:原发性肝癌TACE术前使用静脉持续泵入恩度治疗的临床疗效较好,在提高临床疗效及控制复发转移方面具有较好的效果,且安全性值得肯定,因此本治疗方案的临床应用价值较高。
Objective:To observe and evaluate the clinical effect of Endostar by continuous intravenous infusion in the treatment of patients with primary carcinoma of liver before the transcatheter arterial chemoembolization(TACE)operation.Methods:Sixty-six patients with involved and primary carcinoma of liver in our hospital from October 2015 to March 2016 were involved and divided into control group(TACE operation group,33 cases)and observation group(TACE operation combined with Endostar group,33 cases)according to the difference of treatment methods.Then the clinical effect,toxic side effects rates,tumor markers,as well as recurrence and metastasis related indexes before and after the treatment were analyzed and compared.Results:The total clinical efficiency of observation group was significantly higher than that of control group(P<0.05),the tumor markers and recurrence and metastasis related indexes after the treatment were lower than those of control group(P<0.05),while the toxic side effects rates of two groups had no significant differences(P>0.05).Conclusion:Endostar by continuous intravenous infusion can ef-fectively improve the clinical effect and control the recurrence and metastasis in the treatment of patients with primary carcinoma of liver before the TACE operation with higher clinical safty,thus,it has a better clinical applied value.
出处
《武汉大学学报（医学版）》
CAS
2018年第3期497-501,共5页
Medical Journal of Wuhan University
基金
海南省医药卫生科研项目(编号:14A210248)
关键词
原发性肝癌
经肝动脉化疗栓塞术
恩度
临床疗效
Primary Carcinoma of Liver
Transcatheter Arterial Chemoembolization
Endostar
Clinical Effect
