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白虎汤治疗原发性肝癌TACE术后患者的临床疗效及预后的影响研究 被引量:10

Clinical efficacy of baihu tang in patients with primary liver cancer after TACE
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摘要 [目的]研究白虎汤治疗对原发性肝癌TACE术后患者的基质金属酶水平及T细胞亚群的影响。[方法]以2012年10月~2014年7月我院收治的120例原发性肝癌并行TACE术后有发热症状的患者作为研究对象,根据随机数字表法分成研究组和对照组,每组60例。对照组患者进行常规的西医治疗,口服头孢克无分散片,2次/d,100mg/次,予消炎痛栓纳肛,2次/d,50mg/次,疗程10d。研究组在对照组基础上予以白虎汤加减治疗,早晚各一剂,疗程10d。一个疗程结束后评价2组患者的疗效及不良反应情况,比较治疗前后基质金属蛋白酶以及T细胞亚群的改变情况,同时评估随访半年、1年和2年患者的生存率和复发率。[结果]1个疗程治疗后研究组患者的有效率(90.00%)明显高于对照组(71.67%),差异有统计学意义(P<0.05)。治疗后研究组患者的MMP-1、MMP-3、MMP-9水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后研究组患者CD3+、CD4+细胞亚群以及CD4+/CD8+比值显著升高,差异有统计学意义(P<0.05),治疗后研究组患者CD3+、CD4+细胞亚群以及CD4+/CD8+比值明显高于对照组,差异有统计学意义(P<0.05)。治疗后对照组患者的ALT和AST水平明显高于研究组,差异有统计学意义(P<0.05)。治疗后半年、1年、2年2组患者的生存率逐渐降低,且对照组患者的生存率低于研究组,仅随访第2年生存率之间的差异有统计学意义(P<0.05)。治疗后研究组半年、1年和2年内肿块的复发率均明显低于对照组,差异有统计学意义(P<0.05)。[结论]白虎汤治疗原发性肝癌TACE术后具有一定的疗效,且安全性高,能够增强患者的免疫保护和保肝降酶作用,对于术后复发具有一定的预防作用,有很好的临床应用前景。 [Objective]To study the clinical efficacy of Baihu Decoction on patients with primary liver cancer after TACE,we analysed the level of MMPs and the proportion of T lymphocyte subpopulation in baihu tang treated and non-treated liver cancer patients after TACE.[Methods]From October 2012 to July2014,120 patients with primary liver cancer who had fever after TACE were divided into study group(60 cases)and control group(60 cases)randomly.The patients in the control group were treated with conventional western medicine,and cefaclor was orally administered twice daily,100 mg/time,and indomethacinsuppository was given twice a day for 10 days.Patients in the study group were treated with conventional western medicine combined Baihu Tang,10 days for a course.At the end of one course of treatment,the clinical efficacy and side effects were evaluated.The level of matrix metalloproteinases(MMPs)and the proportion of T lymphocyte subpopulation before and after treatment were compared.The 6 months,1 year and 2 years survival and recurrence rates were also assessed in patients.[Results]The effective rate(90.00%)in the study group was significantly higher than that in the control group(71.67%)(P〈0.05).The levels of MMP-1,MMP-3 and MMP-9 in the study group were significantly lower than those in the control group(P〈0.05).The ratio of CD3+,CD4+and CD4+/CD8+in the study group were significantly increased(P〈0.05),and the ratios of CD3+,CD4+and CD4+/CD8+in the study group were significantly higher than those in the control group(P〈0.05).The levels of ALT and AST in the control group were significantly higher than those in the study group(P〈0.05).The 2 years survival rate of the study group was higher than control group(P〈0.05).The 6 months,1 year and 2 years recurrence rate of the patients in the study group was significantly lower than the control group(P〈0.05).[Conclusion]We found that liver cancer patients after TACE could be treated with Baihu Tang,which
出处 《中国中西医结合消化杂志》 CAS 2017年第11期850-854,共5页 Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词 白虎汤 原发性肝癌 基质金属酶 TACE术后 免疫保护 Baihu Tang primary liver cancer matrix metalloenzyme TACE immune protection
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