摘要
目的观察干扰素治疗宫颈人乳头瘤病毒(HPV)亚临床感染的疗效。方法将2012年2月至2014年3月期间我院妇产科收治的112例HPV亚临床感染患者按随机数表法分为观察组和对照组,各56例,观察组在月经结束后3d开始给予重组人干扰素α-2b栓阴道塞入治疗,对照组在月经结束后3 d开始使用双唑泰栓阴道塞入治疗,3个疗程(1个月)后比较两组患者的治疗效果,并比较治疗前后两组患者的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、HPV转阴情况以及不良反应发生率。结果观察组患者的治疗总有效率为96.4%(54/56),明显高于对照组的83.9%(47/56),差异有统计学意义(P<0.05);观察组和对照组治疗后的TNF-α水平分别为(88.2±22.1)ng/L和(105.2±21.6)ng/L,显著低于治疗前的(158.2±21.8)ng/L和(157.1±21.4)ng/L,差异均有显著统计学意义(P<0.01);治疗后IL-6水平分别为(8.9±3.3)ng/m L和(6.4±3.2)ng/m L,显著高于治疗前的(5.4±2.8)ng/m L和(5.5±2.7)ng/m L,差异均有显著统计学意义(P<0.01);且治疗后观察组的TNF-α水平显著低于对照组,IL-6水平显著高于对照组,差异均有显著统计学意义(P<0.01);随访1年,观察组患者转阴率为98.2%(55/56),明显高于对照组的89.3%(50/56),差异有统计学意义(P<0.05);观察组不良反应发生率为5.4%(3/56),对照组为7.1%(4/56),差异无统计学意义(P>0.05)。结论干扰素治疗宫颈HPV亚临床感染具有确切疗效,其可增强患者免疫力,减少复发,同时不良反应较轻,安全可靠,使用方便,值得推广。
Objective To discuss the clinical effects of interferon in the treatment of patients with human papilloma virus(HPV) subclinical infection. Methods A total of 112 patients with HPV subclinical infection were randomly divided into the observation group(n=56) and the control group(n=56) from February 2012 to March 2014. The observation group was treated with recombinant human interferon alpha-2b suppository 3 d after the end of menstruation, and the control group was treated with metronidazole 3 d after the end of menstruation. The treatment effects of two groups were compared after 3 courses(1 month). The serum tumor necrosis factor alpha(TNF-α), leukocyte interleukin 6(IL-6), HPV negative rate and adverse reaction before and after treatment of two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group [96.4%(54/56) vs 83.9%(47/56)], P<0.05). After treatment, TNF-α level in observa-tion group and control group were significantly lower than before treatment [(88.2± 22.1) ng/L vs(158.2± 21.8) ng/L,(105.2± 21.6) ng/L vs(157.1±21.4) ng/L, P<0.01]. After treatment,IL-6 levels were significantly higher than before treatment [(8.9±3.3) ng/m L vs(5.4±2.8) ng/m L,(6.4±3.2) ng/m L vs(5.5±2.7) ng/m L, P<0.01]. After treatment, the level of TNF-α in the observation group was significantly lower than that of the control group, and the level of IL-6 was significantly higher than that of the control group, with statistically significant difference(P<0.01). During the follow-up of one year, the HPV negative rate of patients in the observation group was significantly higher than that of the control group [98.2%(55/56) vs 89.3%(50/56)], and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was lower than that of the control group [5.4%(3/56) vs 7.1%(4/56)], but the difference was not statistically significant(P>0.05). Conclusion Interferon has significant curative effect in pati
出处
《海南医学》
CAS
2016年第10期1619-1621,共3页
Hainan Medical Journal
关键词
干扰素
人乳头瘤病毒
亚临床感染
血清肿瘤坏死因子-Α
白细胞介素-6
Interferon
Human papilloma virus(HPV)
Subclinical infection
Serum tumor necrosis factor alpha(TNF-α)
Leukocyte interleukin 6(IL-6)
