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初诊2型糖尿病患者血清活性维生素D3水平的变化及其临床意义 被引量:3

Changes of serum active vitamin D_3 levels in newly diagnosed type 2 diabetic patients and its clinical significance
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摘要 目的观察初诊2型糖尿病患者血清活性维生素D3水平的变化情况,为临床治疗和干预提供理论依据。方法选取2014年1月至2015年6月期间就诊于我院干部病科和内分泌科的200例2型糖尿病患者设为观察组,选取同期就诊于我院的100健康查体者作为对照组。比较两组受检者的年龄、病程、体质指数(BMI)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及胰岛素分泌指数(HOMR-β)、胰岛素抵抗指数(HOMR-IR)、血清活性维生素D3水平,以及谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酐(CRE)、血钙、血磷水平。结果 (1)两组受检者的血清TG、TC、ALT、AST、CRE、血钙、血磷水平比较差异均无统计学意义(P>0.05);(2)与对照组比较,观察组患者的FPG[(9.85±2.50)mmol/L vs(4.84±0.54)mmol/L]、2 h PG[(10.28±2.28)mmol/L vs(5.21±0.56)mmol/L]、Hb A1c[(7.66±2.36)%vs(4.62±0.47)%]明显升高,FINS[(7.40±5.06)μU/ml vs(11.87±6.81)μU/ml]、HOMR-β[(25.81±20.13)vs(254.33±102.14)]、1,25-(OH)D3[(15.57±3.58)ng/ml vs(51.72±8.96)ng/ml]水平明显降低,差异具有统计学意义(P<0.05),而HOMR-IR[(3.40±2.83)vs(2.32±0.63)]与对照组比较差异无统计学意义(P>0.05);(3)1,25-(OH)D3与HOMR-β呈正相关(r=0.72,P<0.05),与HOMR-IR无明显相关性(r=-0.11,P>0.05)。结论初诊2型糖尿病患者血清1,25-(OH)D3降低,低1,25-(OH)D3水平影响患者的胰岛素β细胞的分泌功能。 Objective To analyze the changes of serum active vitamin D3 levels in newly diagnosed type 2 diabetic patients, and to provide theoretical basis for clinical treatment and intervention. Methods Two hundred patients with type 2 diabetes mellitus who were treated in our hospital from Jan. 2014 to Jun. 2015 were selected as the observation group, and 100 healthy individuals who came to our hospital for physical examination during the same period were enrolled as the control group. The age, course of disease, body mass index(BMI), triglyceride(TG), high-density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C), HOMR-β, HOMR-IR, and serum active vitamin D3 levels were compared between the two groups, as well as alanine aminotransferase(ALT), aspartate aminotransferase(AST), creatinine(CRE), serum calcium, serum phosphorus levels. Results(1) There were no statistically significant difference in serum TG, TC, ALT, AST, CRE, serum calcium, serum phosphorus levels between the two groups(P>0.05).(2) Compared with the control group, FPG [(9.85±2.50) mmol/L vs(4.84±0.54) mmol/L], 2 h PG [(10.28±2.28) mmol/L vs(5.21±0.56) mmol/L], Hb A1 c [(7.66±2.36)% vs(4.62±0.47)%] of the observation group were significantly higher, while FINS [(7.40±5.06) μU/ml vs(11.87±6.81) μU/ml], HOMR-β [(25.81±20.13) vs(254.33±102.14)], 1,25-(OH)D3[(15.57±3.58) ng/ml vs(51.72±8.96) ng/ml] were significantly lower(P<0.05). There was no significant difference between the observation group and the control group in HOMR-IR levels [(3.40±2.83) vs(2.32±0.63)](P>0.05).(3) 1,25-(OH)D3was positively correlated with HOMR-β(r=0.73, P<0.05), but it showed no significant correlation with HOMR-IR(r=-0.11,P>0.05). Conclusion 1,25-(OH)D3decreases in patients with newly diagnosed type 2 diabetes mellitus, and low 1,25-(OH)D3levels affect the secretion of insulin beta cells in patients.
出处 《海南医学》 CAS 2016年第5期769-771,共3页 Hainan Medical Journal
关键词 2型糖尿病 活性维生素D3 胰岛素抵抗 临床意义 Type 2 diabetes mellitus Active vitamin D3 Insulin resistance Clinical significance
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  • 1陈姗,刘志红,王瑞石,孙骅,陈丹,陈朝红,黎磊石.糖尿病肾病疾病进展相关基因的基因组学研究[J].中华肾脏病杂志,2006,22(9):528-534. 被引量:13
  • 2程洪燕.2型糖尿病与相关致病因素研究进展[J].临床心身疾病杂志,2007,13(2):190-191. 被引量:6
  • 3谢恺庆,廖松,张绍峰,杨海波,孙安远.维持性血液透析患者微炎症状态与胰岛素抵抗的关系[J].临床荟萃,2007,22(18):1304-1306. 被引量:7
  • 4Norman AW, Frankel JB, Heldt AM ,et al. Vitamin D deficiency inhibits pancreatic secretiou of insulin[ J ]. Science, 1980, 209 (4458) :823-825. 被引量:1
  • 5Bourlon PM, Faure-Dussert A, Billaudel B. The de novo synthesis of numerous proteins is decreased dining vitamin D3 deficiency and is gradually restored by 1, 25-dihydroxyvitamin D3 repletion in the islets of Langerhans of rats [ J ]. J Endocrinol, 1999,162 ( 9 ) : 101-109. 被引量:1
  • 6Borissova AM, Tankova T, Kirilov G, et at. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients[ J ]. Int J Clin Pract, 2003,57 (4) :258-261. 被引量:1
  • 7内科学[M].第8版.北京:人民卫生出版社,2013:733. 被引量:1
  • 8Sit D, Kadiroglu AK, Yilmaz ME, et al. The prevalence of insulin re- sistance and its relationship between anemia, secondary hyperpara- thyroidism, inflammation, and cardiac parameters in chronic hemo- dialysis patients [J]. Ren fail, 2005, 27(4): 403--407. 被引量:1
  • 9Guebre-Egziabher F, Kalbacher E, Fouque D, et al. Insulin resis- tance and inflammation in chronic kidney diseases [J]. Ncphrol Ther, 2009, 5(5): 346-352. 被引量:1
  • 10Diez JJ, Iglesias P, Fernandez-Reyes MJ, et al. Serum concentra- tions of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease [J]. Clin Endocrinol (Oxf), 2005, 62(2): 242-249. 被引量:1

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